UC-764865 chemical structure
Chemical structureResearch use only
CAT. NO. DC70862Featured

UC-764865

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Product overview

Description & Application

UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.

ParameterValue
Chemical NameUC-764865
CAS No.2566480-63-3
Synonyms2-Propen-1-one, 1-(4-methoxyphenyl)-3-[(6-methyl-1H-benzimidazol-2-yl)thio]-, (2Z)-
FormulaC18H16N2O2S
M.Wt324.396842956543
SMILESC(C1=CC=C(OC)C=C1)(=O)/C=C\SC1NC2=CC(C)=CC=C2N=1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.

In Vitro

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In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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