VHL ligand 2 hydrochloride ((S,R,S)-AHPC-Me hydrochloride) chemical structure
Chemical structureResearch use onlyView full-size structure
CAT. NO. DC26119Featured

VHL ligand 2 hydrochloride ((S,R,S)-AHPC-Me hydrochloride)

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Product overview

Description & Application

VHL ligand 2 hydrochloride is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology.

ParameterValue
Chemical NameVHL ligand 2 hydrochloride ((S,R,S)-AHPC-Me hydrochloride)
CAS No.1948273-03-7
SynonymsVHL ligand 2 hydrochloride
FormulaC23H33ClN4O3S
M.Wt481.06
SMILESCc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1.Cl
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Chemical identity references

Biological Activity

VHL ligand 2 hydrochloride is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology.

In Vitro

E3 ligase Ligand 1 is a VHL E3 ligase-binding ligand[1]. E3 ligase Ligand 1 is used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC. ARV-771, a small-molecule pan-BET degrader based on proteolysis-targeting chimera (PROTAC) technology, demonstrates dramatically improved efficacy in cellular models of castration-resistant prostate cancer (CRPC) as compared with BET inhibition[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

Ligand for E3 Ligase[1]

References & source

[1]. WO/2017/030814A1

[2]. Kanak R, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America (2016), 113(26), 7124-7129

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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