PSB-16671 chemical structure
Chemical structureResearch use only
CAT. NO. DC70714Featured

PSB-16671

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TotalUS$450
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Product overview

Description & Application

PSB-16671 is a novel orthosteric and allosteric activator of GPR84, activates human GPR84 with EC50 of 41.3 nM in cAMP accumulation assays. PSB-16671 is selective versus related fatty acid receptors and the arylhydrocarbon receptor. PSB-16671 shows an EC50 of 5.47 uM in β-Arrestin assays, and allosteric KB value of 634 nM.

ParameterValue
Chemical NamePSB-16671
CAS No.2094630-35-8
Synonyms3,3′-Methylenebis[5,7-difluoro-1H-indole];PSB-16671;3,3'-Methylenebis[5,7-difluoro-1H-indole]
FormulaC17H10F4N2
M.Wt318.268317699432
SMILESC12=C(C(=CC(=C1)F)F)NC=C2CC1=CNC2C(F)=CC(F)=CC1=2
Purity>97%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

PSB-16671 is a novel orthosteric and allosteric activator of GPR84, activates human GPR84 with EC50 of 41.3 nM in cAMP accumulation assays. PSB-16671 is selective versus related fatty acid receptors and the arylhydrocarbon receptor. PSB-16671 shows an EC50 of 5.47 uM in β-Arrestin assays, and allosteric KB value of 634 nM.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

1. Sarah J Mancini, et al. Sci Rep. 2019 Feb 12;9(1):1861

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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