Leuprorelin chemical structure
Chemical structureResearch use only
CAT. NO. DC22504Featured

Leuprorelin

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TotalUS$850
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Product overview

Description & Application

Leuprolide is an agonist at pituitary GnRH receptors. Target: GnRH receptorLeuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer, endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary, inducing a transient early rise in gonadotrophin release. With continued use, Leuprorelin causes pituitary desensitisation and/or down-regulation, leading to suppressed circulating levels of gonadotrophins and sex hormones. [1] By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes. [2]

ParameterValue
Chemical NameLeuprolide acetate
CAS No.53714-56-0
SynonymsLeuprorelin;5-OXOPRO-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHC2H5;[DES-GLY10, DLEU6, PRO9]-LH-RH, ETHYL AMIDE;[DES-GLY10, DLEU6, PRO9]-LUTEINIZING HORMONE-RELEASING HORMONE, ETHYL AMIDE;[DES-GLY10, DLEU 6, PRONHET9];(DES-GLY10,D-LEU6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE;(DES-GLY10,D-LEU6,PRO-NHET9)-LHRH;[DES-GLY10, D-LEU6, PRO-NHET9]-LH-RH (HUMAN);(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE;[DES-GLY10, D-LEU6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE HUMAN;DES-GLY10,[P-LEU6]-LH-RH ETHYLAMIDE;GLP-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET;LEUPROLIDE ACETATE;LEUPROLIDE (HUMAN);LEUPRORELIN ACETATE;LH-RH LEUPROLIDE;PGLU-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET;[DES-GLY10,DLEU6, PRONHET9] LH-RH LEUPROLIDE;Leuprolide; LHRH ethylamide;5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide;Carcinil;des-Gly10 ethylamide]gonadotropin releasing hormone;Enantone;GLP-HIS-TRP-SER-TYR-DLEU-LEU-ARG-PRO-NHET: GLP-HWSY-DL-LRP-NHET;Leuplin;LEUPROPELIN;Lucrin;nghormone;pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHC2H5;Luteinizinghormone-releasing factor (pig),6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-;(D-Leu6,des-Gly-NH210)-LH-RH ethylamide;A43818;D-Leu6-des-Gly10-LH-releasing hormone ethylamide;Des-Gly10-[D-Leu6]-LH-releasing hormone ethylamide;Des-Gly10-[D-Leu6]LH-RHethylamide;1-9-Luteinizinghormone-releasing factor (swine), 6-D-leucine-9-(N-ethyl-L-prolinamide)-;Lupron SR;NSC 377526;1: PN: WO02087616 PAGE: 31 claimed protein;Lupron;Leuprolide acetate salt;Prostap;Lutrate;Onectyl;Enanton;leuprolide-acetate;DSSTox_RID_83201;DSSTox_CID_28935;DSSTox_GSID_49009;MLS000028695;RGLRXNKKBLIBQS-XNHQSDQCSA-N;Tox21_113507;SMR00005894
FormulaC61H88N16O14
M.Wt1269.4502
SMILESCC(O)=O.NC(N)=NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC2N=CNC=2)NC(=O)[C@H]3NC(=O)CC3)CC4C5=C(C=CC=C5)NC=4)C(=O)N6[C@@H](CCC6)C(=O)NCC
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Leuprolide is an agonist at pituitary GnRH receptors. Target: GnRH receptorLeuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer, endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary, inducing a transient early rise in gonadotrophin release. With continued use, Leuprorelin causes pituitary desensitisation and/or down-regulation, leading to suppressed circulating levels of gonadotrophins and sex hormones. [1] By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes. [2]

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Plosker GL, Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders. Drugs.1994 Dec;48(6):930-967.

[2]. Leuprorelin

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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