MX69 chemical structure
Chemical structureResearch use only
CAT. NO. DC10074Featured

MX69

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TotalUS$550
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Product overview

Description & Application

MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.

ParameterValue
Chemical NameMX 69; MX-69
CAS No.1005264-47-0
SynonymsMX 69; MX-69
FormulaC27H26N2O4S
M.Wt474.57
SMILESO=C(O)C1=CC=C(C2C(CC=C3)C3C(C=C(S(=O)(NC4=CC(C)=C(C)C=C4)=O)C=C5)=C5N2)C=C1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.

In Vitro

MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro[1].

In Vivo

MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheetRequest COA / MSDS

Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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