ZINC02092166 chemical structure
Chemical structureResearch use only
CAT. NO. DC21852Featured

ZINC02092166

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Product overview

Description & Application

ZINC02092166 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 1.7 and 7.0 uM in AlphaScreen and FP assay (wild-type β-catenin), respectively; remain affinity for muant catenin V511S, V511S/I569S and R469A with Ki of 20-50 uM; exhibits dual selectivity for β-catenin/Tcf over β-catenin/cadherin and β-catenin/APC PPIs.

ParameterValue
Chemical Name4-amino-N'-{13-oxa-10,12,14,16-tetraazatetracyclo7.7.0.0^{2,7}.0^{11,15}hexadeca-1(16),2,4,6,9,11,14-heptaen-8-ylidene}-1,2,5-oxadiazole-3-carbohydrazide
CAS No.354543-09-2
SynonymsBDBM50094590;J3.583.511C;(E)-4-amino-N'-(9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene)-1,2,5-oxadiazole-3-carbohydrazide;(Z)-4-Amino-N'-(9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene)-1,2,5-oxadiazole-3-carbohydrazide;4-Amino-N'-(9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene)-1,2,5-oxadiazole-3-carbohydrazide;4-Amino-N'-[(9Z)-;Nc1nonc1C(=O)N\N=C1\c2ccccc2-c2nc3nonc3nc12;LQZ-7F;4-amino-N'-{13-oxa-10,12,14,16-tetraazatetracyclo7.7.0.0^{2,7}.0^{11,15}hexadeca-1(16),2,4,6,9,11,14-heptaen-8-ylidene}-1,2,5-oxadiazole-3-carbohydrazide
FormulaC14H7N9O3
M.Wt349.26388001442
SMILESO1N=C2C(N1)=NC1=C(C3C=CC=CC=3C1=N2)/N=N/C(C1C(N)=NON=1)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

ZINC02092166 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 1.7 and 7.0 uM in AlphaScreen and FP assay (wild-type β-catenin), respectively; remain affinity for muant catenin V511S, V511S/I569S and R469A with Ki of 20-50 uM; exhibits dual selectivity for β-catenin/Tcf over β-catenin/cadherin and β-catenin/APC PPIs.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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