Chemical structureResearch use only

CAT. NO. DC48424Featured

Enbezotinib

Name: Enbezotinib
Brand: DC Chemicals
SKU: DC48424
Price: 650.0 USD

Pack Sizes & Prices

TotalUS$650

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Product overview

Description & Application

Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer[1].

Parameter	Value
Chemical Name	Enbezotinib
CAS No.	2359649-81-1
Formula	C21H21FN6O3
M.Wt	424.43
SMILES	FC1=CC(CN2[C@H](CCC3)[C@H]3OC(C2=N4)=CN5C4=C6C=N5)=C(O[C@@H](C)CNC6=O)N=C1
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer[1].

In Vitro

Enbezotinib (compound 5) (0.3-300 nM) inhibits p-RET (y905) in RET-driven cells[1].

In Vivo

Enbezotinib (compound 5) (2-5 mg/kg; twice daily for 27 days) decreases tumor size in mice[1].

References & source

[1]. ROGERS EW, et, al. Macrocyclic compounds for treating disease. WO2019126121A1.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheet Request COA / MSDS

Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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