DC Chemicals · Product datasheet

Enbezotinib — Datasheet

CAT. NO. DC48424

Product page and current package options

ParameterValue
Chemical NameEnbezotinib
CAS No.2359649-81-1
FormulaC21H21FN6O3
M.Wt424.43
SMILESFC1=CC(CN2[C@H](CCC3)[C@H]3OC(C2=N4)=CN5C4=C6C=N5)=C(O[C@@H](C)CNC6=O)N=C1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer[1].

In Vitro

Enbezotinib (compound 5) (0.3-300 nM) inhibits p-RET (y905) in RET-driven cells[1].

In Vivo

Enbezotinib (compound 5) (2-5 mg/kg; twice daily for 27 days) decreases tumor size in mice[1].

References & source

[1]. ROGERS EW, et, al. Macrocyclic compounds for treating disease. WO2019126121A1.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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