EPZ-719 chemical structure
Chemical structureResearch use only
CAT. NO. DC47616Featured

EPZ-719

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TotalUS$750
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Product overview

Description & Application

EPZ-719 is a novel and potent SETD2 inhibitor ( IC50 = 0.005 μM) with a high selectivity over other histone methyltransferases.

ParameterValue
Chemical NameEPZ-719
CAS No.2697176-16-0
SynonymsEPZ-719;EPZ 719;EPZ719
FormulaC22H31FN4O3S
M.Wt450.57
SMILESN1C2=C(C(F)=CC=C2C)C=C1C(N[C@@H]1CCC[C@H](N2CC[C@H](N(C)S(C)(=O)=O)C2)C1)=O
Purity>97%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

EPZ-719 is a novel and potent SETD2 inhibitor ( IC50 = 0.005 μM) with a high selectivity over other histone methyltransferases.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Lampe JW, et al. Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies. ACS Med Chem Lett. 2021 Aug 24;12(10):1539-1545.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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