IRES-J007 chemical structure
Chemical structureResearch use only
CAT. NO. DC22995Featured

IRES-J007

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TotalUS$300
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Product overview

Description & Application

IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.

ParameterValue
Chemical NameN-(2,4-Dimethoxybenzyl)phthalimide
CAS No.155514-72-0
Synonyms2-(2,4-dimethoxybenzyl)isoindoline-1,3-dione;N-(2,4-Dimethoxybenzyl)phthalimide;2-[(2,4-dimethoxyphenyl)methyl]isoindole-1,3-dione
FormulaC17H15NO4
M.Wt297.3053
SMILESO(C([H])([H])[H])C1C([H])=C(C([H])=C([H])C=1C([H])([H])N1C(C2=C([H])C([H])=C([H])C([H])=C2C1=O)=O)OC([H])([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

References 1. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59. View Related Products by Target c-Myc

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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