Sarolaner (PF-6450567) is an orally active, broad-spectrum ectoparasiticide, has efficacy against fleas and ticks on dogs, with LC80 of 0.3 μg/mL against C. felis and an LC100 of 0.003 μg/mL against O. turicata[1].
Parameter
Value
Chemical Name
Sarolaner
CAS No.
1398609-39-6
Synonyms
Sarolaner;DM113FTW7F;1-[6-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone;(S)-1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethan-1-one;Sarolaner [USAN:INN];Simparica;Sarolaner (USAN/INN);1-(5'-((5S)-5-(3,5;PF-6450567;UNII-DM113FTW7F;FLEFKKUZMDEUIP-QFIPXVFZSA-N;sarolanerum;SCHEMBL12097270;Sarolaner [USAN];Sarolaner(PF-6450567);1-[5'-[(5S)-5-(3,5-Dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]spiro[azetidine-3,1'(3'H)-isobenzofuran]-1-yl]-2-(methylsulfonyl)ethanone;G14568;STRONGHOLD PLUS COMPONENT SAROLANER;1-(5'-((5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'-H-spiro(azetidine-3,1'-(2)benzofuran)-1-yl)-2-(methylsulfonyl)ethanone;DA-67413;CHEMBL3137302;Sarolaner 100 microg/mL in Acetonitrile;(S)-1-(5'-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone;SAROLANER [GREEN BOOK];DTXSID101336934;Q27276475;SAROLANER [INN];SAROLANER COMPONENT OF STRONGHOLD PLUS;AKOS040742613;PF6450567;SAROLANER [MI];SAROLANER (EMA EPAR VETERINARY);SAROLANER [EMA EPAR VETERINARY];Ethanone, 1-(5'-((5S)-5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl)spiro(azetidine-3,1'(3'H)-isobenzofuran)-1-yl)-2-(methylsulfonyl)-;MS-30427;CS-0012328;HY-16730;Simparica Chewables;EX-A5583;1398609-39-6;D10668
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological Activity
Sarolaner (PF-6450567) is an orally active, broad-spectrum ectoparasiticide, has efficacy against fleas and ticks on dogs, with LC80 of 0.3 μg/mL against C. felis and an LC100 of 0.003 μg/mL against O. turicata[1].
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
No in vivo data are provided in the current product source. Contact us for further information.
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.
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