DC Chemicals · Product datasheet

Sarolaner(PF-6450567) — Datasheet

CAT. NO. DC12047

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ParameterValue
Chemical NameSarolaner
CAS No.1398609-39-6
SynonymsSarolaner;DM113FTW7F;1-[6-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone;(S)-1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethan-1-one;Sarolaner [USAN:INN];Simparica;Sarolaner (USAN/INN);1-(5'-((5S)-5-(3,5;PF-6450567;UNII-DM113FTW7F;FLEFKKUZMDEUIP-QFIPXVFZSA-N;sarolanerum;SCHEMBL12097270;Sarolaner [USAN];Sarolaner(PF-6450567);1-[5'-[(5S)-5-(3,5-Dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]spiro[azetidine-3,1'(3'H)-isobenzofuran]-1-yl]-2-(methylsulfonyl)ethanone;G14568;STRONGHOLD PLUS COMPONENT SAROLANER;1-(5'-((5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'-H-spiro(azetidine-3,1'-(2)benzofuran)-1-yl)-2-(methylsulfonyl)ethanone;DA-67413;CHEMBL3137302;Sarolaner 100 microg/mL in Acetonitrile;(S)-1-(5'-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone;SAROLANER [GREEN BOOK];DTXSID101336934;Q27276475;SAROLANER [INN];SAROLANER COMPONENT OF STRONGHOLD PLUS;AKOS040742613;PF6450567;SAROLANER [MI];SAROLANER (EMA EPAR VETERINARY);SAROLANER [EMA EPAR VETERINARY];Ethanone, 1-(5'-((5S)-5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl)spiro(azetidine-3,1'(3'H)-isobenzofuran)-1-yl)-2-(methylsulfonyl)-;MS-30427;CS-0012328;HY-16730;Simparica Chewables;EX-A5583;1398609-39-6;D10668
FormulaC23H18Cl2F4N2O5S
M.Wt581.364037036896
SMILESClC1C(=C(C=C(C=1)[C@]1(C(F)(F)F)CC(C2C=CC3=C(C=2)COC23CN(C(CS(C)(=O)=O)=O)C2)=NO1)Cl)F
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Sarolaner (PF-6450567) is an orally active, broad-spectrum ectoparasiticide, has efficacy against fleas and ticks on dogs, with LC80 of 0.3 μg/mL against C. felis and an LC100 of 0.003 μg/mL against O. turicata[1].

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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