Metabolic enzymes, lipid and glucose metabolism and hormone signaling.
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Other Research Tools (75) · Additional reagents, building blocks and specialized research tools.
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CAS 1916571-90-8
NCT-503 is a PHGDH inhibitor for studying serine synthesis, one-carbon metabolism and metabolic dependencies in cancer models. Published studies distinguish biochemical inhibition from cellular growth effects and document context-dependent off-target activity.
CAS 1700637-55-3
CD38 inhibitor 78c is a reversible CD38 NADase inhibitor for NAD+ metabolism and aging research. Published work links CD38 inhibition to cellular NAD+ elevation and functional changes in mouse aging models.
CAS 866399-87-3
Obicetrapib, also known as TA-8995, is a CETP inhibitor for lipoprotein metabolism and cholesterol-efflux research.
CAS 252917-06-9
CHIR-99021 (CT99021) is a GSK-3 inhibitor used in signaling, cell-state and metabolic research.
CAS 1380424-42-9
KML-29 is a selective MAGL inhibitor used to investigate endocannabinoid metabolism, inflammatory pain and neuropathic pain.
CAS 1628805-46-8
IDH-305 (IDH305) is an allosteric mutant-IDH1 inhibitor for studies of 2-hydroxyglutarate production and IDH1-mutant cancer biology.
CAS 923978-27-2
Elafibranor (GFT505) is a dual PPARα/δ agonist used in hepatic lipid metabolism, inflammation and fibrosis research.
CAS 2377576-35-5
BAY-3827 is an AMPK inhibitor with additional RSK-family activity, used to study metabolic signaling and androgen-dependent prostate cancer.
CAS 1415562-82-1
PF-543 is a potent, sphingosine-competitive SPHK1 inhibitor for investigating S1P production and sphingolipid signaling.
CAS 1429505-03-2
Soticlestat is a cholesterol 24-hydroxylase inhibitor used in cholesterol turnover and neuronal-excitability research.
CAS 2301866-59-9
DO-264 (DO264) is an ABHD12 inhibitor for lysophosphatidylserine metabolism and immune-lipid signaling research.
CAS 1394371-71-1
MK-8722 is a direct allosteric activator of mammalian AMPK complexes for metabolic signaling and glucose-homeostasis research.
CAS 6778-33-2
Delta-valerobetaine is a microbiome-derived metabolite used to investigate mitochondrial fatty-acid oxidation and diet-dependent obesity.
CAS 421581-52-4
AG1 is a small-molecule G6PD activator for enzyme oligomerization, NADPH metabolism and redox research.
CAS 1256565-36-2
PTC299 (Emvododstat) is a DHODH inhibitor for pyrimidine metabolism and hematological-cancer research.
CAS 32222-06-3
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
CAS 851528-79-5
Seladelpar is an orally active, potent (50% effect concentration EC50 2 nM), and specific PPAR-δ agonist.
CAS 355025-24-0
Ki16425 is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively.
CAS 6501-72-0
VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.Administration of VGX-1027 to NOD mice with spontaneous or accelerated forms of…
CAS 2204289-53-0
SHIN-2 is a novel SHMT inhibitor, increasing survival in NOTCH1-driven mouse primary T-ALL in vivo
CAS 658084-64-1
FK866 is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) with an IC50 of 0.09 nM.
CAS 846589-98-8
Lorcaserin (APD-356, trade name upon approval Belviq,expected trade name during development, Lorqess is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic. For the detailed information about the…
CAS 603139-19-1
Odanacatib (MK-0822) is a potent and selective inhibitor of cathepsin K, with an IC50 of 0.2 nM for human cathepsin K.
CAS 468740-43-4
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM.
CAS 182431-12-5
Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
CAS 420831-40-9
AK-7 is a selective cell- and brain-permeable SIRT2 inhibitor, with an IC50 of 15.5 μM.
CAS 943962-47-8
BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM.
CAS 1197300-24-5
TGR5 Receptor Agonist, a potent TGR5(GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).
CAS 91396-88-2
PluriSln 1 is an inhibitor of stearoyl-coA desaturase (SCD), and is a pluripotent cell-specific inhibitor.
CAS 65646-68-6
Fenretinide is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
CAS 1218942-37-0
GKT137831 is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.
CAS 591778-68-6
CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACCase) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431.
CAS 1432660-47-3
AGI-6780 that potently and selectively inhibits the tumor-associated mutant IDH2R140Q with IC50 of 23±1.7 nM. AGI-6780 is less potent against IDH2WT with IC50 of 190±8.1 nM.
CAS 102121-60-8
AM580 is a selective RARα agonist with IC50 and EC50 of 8 nM and 0.36 nM, respectively.
CAS 200484-11-3
GMX1778(CHS-828) is a potent inhibitor of NAD+ biosynthesis enzyme NAMPT with IC50 <25 nM.
CAS 1221277-90-2
GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively.
CAS 13299-99-5
MAT2A inhibitor-2 is a methionine adenosyltransferase 2A (MAT2A) inhibitor.
CAS 885101-89-3
GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.IC50 value: 7.32 (pEC50) [1]Target: GPR40GW9508 is shown to be at least 100-fold…
CAS 920509-32-6
MGL-3196 is a highly selective thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.21 μM.
CAS 1923833-60-6
BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
CAS 1234703-40-2
LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM.IC 50 value: 42 nM (EC50)Target: glucokinasein vitro: LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose…
CAS 75330-75-5
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
CAS 59870-68-7
Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic,…
CAS 924416-43-3
AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with Kds of 1.8 and 3.1 μM, respectively.
CAS 1629229-37-3
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
