Compounds with documented oncology research applications.
Products may appear in more than one category. Counts refer to distinct catalog numbers within each category.
Other Research Tools (75) · Additional reagents, building blocks and specialized research tools.
Combine a keyword, research category and target to narrow the product list.
Loading catalog filters…
CAS 1916571-90-8
NCT-503 is a PHGDH inhibitor for studying serine synthesis, one-carbon metabolism and metabolic dependencies in cancer models. Published studies distinguish biochemical inhibition from cellular growth effects and document context-dependent off-target activity.
CAS 2055397-28-7
WM-1119 is a KAT6A/KAT6B inhibitor for epigenetic and cellular-senescence research. The primary study reports binding selectivity, lymphoma-cell growth inhibition and suppression of lymphoma progression in mice.
CAS 1949837-12-0
ARV-771 is a VHL-recruiting BET protein degrader for prostate cancer and targeted protein degradation research. The primary study reports pan-BET degradation, downstream c-MYC suppression and activity in prostate cancer models.
CAS 2055397-18-5
WM-8014 is a KAT6A/KAT6B inhibitor for chromatin, cellular senescence and cancer research. Published work separates biochemical inhibition, fibroblast growth arrest and responses in a zebrafish liver cancer model.
CAS 881487-77-0
KPT-6566 is a covalent PIN1 inhibitor for cancer signaling research. Published studies connect PIN1 inhibition with oxidative stress, DNA damage, cancer-cell death and reduced lung colonization in mice.
CAS 125316-60-1
CD437 is a retinoid-like research compound with direct DNA polymerase α inhibition and antiproliferative activity in cancer-cell models.
CAS 1628805-46-8
IDH-305 (IDH305) is an allosteric mutant-IDH1 inhibitor for studies of 2-hydroxyglutarate production and IDH1-mutant cancer biology.
CAS 610318-03-1
RGX-104 is an LXR agonist for studying myeloid-derived suppressor cells, ApoE signaling and tumor immune responses.
CAS 1535187-91-7
MC3343 is a nonnucleoside DNMT inhibitor for epigenetic reprogramming, osteoblastic differentiation and osteosarcoma research.
CAS 2377576-35-5
BAY-3827 is an AMPK inhibitor with additional RSK-family activity, used to study metabolic signaling and androgen-dependent prostate cancer.
CAS 3316-02-7
ζ-Stat (ZETA-STAT) is a research inhibitor investigated in atypical PKC signaling and invasive behavior of clear-cell ovarian cancer cells.
CAS 1398051-86-9
LTX-401 is an amphipathic amino-acid derivative for cytolytic cell-death and local tumor-immunology research.
CAS 2093401-33-1
OTS193320 is a SUV39H2 methyltransferase inhibitor for histone methylation, DNA-damage-response and cancer-cell research.
CAS 2093400-18-9
OTS186935 is a SUV39H2 inhibitor with published cellular and xenograft activity, used in histone-methylation and cancer research.
CAS 1042735-18-1
ABC 1183 (ABC1183) is a dual GSK-3/CDK9 inhibitor for cancer-cell proliferation and inflammatory signaling research.
CAS 900308-84-1
KL-1 is a small-molecule disruptor of the super elongation complex for transcriptional elongation and MYC-dependent cancer research.
CAS 900308-51-2
KL-2 is a small-molecule disruptor of the super elongation complex for transcriptional elongation and MYC-dependent cancer research.
CAS 1190948-58-3
Diptoindonesin G is an HSP90 modulator for chaperone biology and endocrine-resistant breast-cancer research.
CAS 61034-15-9
CB-002 (CB002) is a p53-pathway-restoring research compound studied in colorectal cancer cells and apoptosis signaling.
CAS 1034895-42-5
9-ING-41 (Elraglusib) is a cancer-research compound originally developed as a GSK-3β inhibitor. Published work documents model-dependent growth inhibition and additional mechanisms.
CAS 286936-40-1
OTX008 (Calixarene 0118, PTX008) is a galectin-1 inhibitor used in tumor-cell signaling and viability research.
BL-AD008 is an AMPK/ZIPK-directed activator investigated in cervical-cancer apoptosis research.
CAS 1256565-36-2
PTC299 (Emvododstat) is a DHODH inhibitor for pyrimidine metabolism and hematological-cancer research.
CAS 2451481-08-4
Sulfopin is a covalent PIN1 inhibitor used to study prolyl-isomerase signaling and MYC-driven cancer biology.
CAS 2499663-01-1
STM2457 is a catalytic METTL3 inhibitor for RNA methylation, leukemia-cell differentiation and cancer research.
CAS 1439399-58-2
Telaglenastat (CB-839) is a potent and selective inhibitor of glutaminase with an IC50 of less than 50 nM.
CAS 722543-31-9
AZD1152 is a pro-drug of Barasertib-hQPA, which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.
CAS 1358715-18-0
Fluzoparib (SHR-3162) is a novel, potent and orally available inhibitor of PARP; potently inhibited PARP1 enzyme activity and induced DNA double-strand breaks, G2/M arrest and apoptosis in homologous recombination repair (H)-deficient cells, Fluzoparib…
CAS 289499-45-2
Canertinib dihydrochloride (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.
CAS 638156-11-3
CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.
CAS 475489-16-8
NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 0.15 μM, also inhibits InsR, with IC50 of 0.14 μM.
CAS 1374640-70-6
Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.
CAS 2296729-00-3
AMG-510 is a specific covalent inhibitor of K-RAS(G12C) with potential antineoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, thro
CAS 1256580-46-7
The dissociation constant (KD) value of CH5424802 For ALK in an ATP-competitive manner is 2.4 nM. CH5424802 has substantial inhibitory potency against both native ALK and L1196M with Ki of 0.83 nM and 1.56 nM, respectively. CH5424802 prevents…
CAS 882531-87-5
R1530 is the multikinase inhibitor with potential antiangiogenesis and antineoplastic activities.R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial…
CAS 902135-91-5
AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.
CAS 956590-23-1
UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.
CAS 2204289-53-0
SHIN-2 is a novel SHMT inhibitor, increasing survival in NOTCH1-driven mouse primary T-ALL in vivo
CAS 474645-27-7
Monomethyl auristatin E (MMAE) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several…
CAS 761439-42-3
NVP-TAE 684 is a highly potent and selective ALK inhibitor, which blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM.
CAS 1445993-26-9
Mivebresib is a potent and orally available bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM.
CAS 159351-69-6
Everolimus (RAD001) is a potent mTOR inhibitor that binds to FKBP-12 to generate an immunosuppressive complex.
CAS 658084-64-1
FK866 is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) with an IC50 of 0.09 nM.
CAS 755038-65-4
Volasertib is a highly potent Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM, as well as the two closely related kinases PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively.
CAS 935666-88-9
AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. IC50 value: 0.26 nM Target: JAK2 in vitro: AZD1480 demonstrated significant immunoregulatory effects by…
CAS 935888-69-0
Oprozomib (ONX 0912; PR047) is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM.The anti-MM activity of Oprozomib is associated with activation of caspase-8, caspase-9, caspase-3, and PARP, as well as…
