ζ-Stat (ZETA-STAT)

Name: ζ-Stat (ZETA-STAT)
Brand: DC Chemicals
SKU: DC10984
Price: 900.0 USD

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Total$400

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Product overview

Description & Application

ζ-Stat (ZETA-STAT) is a research inhibitor investigated in atypical PKC signaling and invasive behavior of clear-cell ovarian cancer cells.

Parameter	Value
Chemical Name	8-hydroxy-1,3,6-naphthalenetrisulfonic acid
CAS No.	3316-02-7
Synonyms	NSC37044
Formula	C10H8O10S3
M.Wt	384.36
SMILES	O=S(C1=C2C(O)=CC(S(=O)(O)=O)=CC2=CC(S(=O)(O)=O)=C1)(O)=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

PKCζ-associated signaling · Literature evidence

Biological Activity

ζ-Stat (ZETA-STAT) is a research inhibitor investigated in atypical PKC signaling and invasive behavior of clear-cell ovarian cancer cells. ζ-Stat reduced WST-1 viability readouts in a concentration-dependent manner.

In Vitro

Endpoint	Model / conditions / source	Reported result
Growth response	TOV21G and ES-2 ovarian clear-cell carcinoma cells; 1, 3, 5 or 10 µM for 72 h. [1]	ζ-Stat reduced WST-1 viability readouts in a concentration-dependent manner.
Time dependence	3 µM treatment assessed at 24, 48 and 72 h. [1]	Growth responses varied with exposure duration.
Motility and signaling	Migration/invasion and PKCζ–Ect2–Rac1 analyses; Rac1 assay at 10 µM for 72 h. [1]	Reduced motility/invasion accompanied changes in this signaling axis.

In Vivo

No compound-specific animal efficacy result is established by the sources summarized here.

Compound and Evidence Context

Endpoint	Model / conditions / source	Reported result
Target evidence	Cellular and pathway-level study. [1]	The findings do not provide a direct binding Kd or a complete kinome selectivity profile for ζ-Stat.