CD437

Name: CD437
Brand: DC Chemicals
SKU: DC10491
Price: 600.0 USD

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Product overview

Description & Application

CD437 is a retinoid-like research compound with direct DNA polymerase α inhibition and antiproliferative activity in cancer-cell models.

Parameter	Value
Chemical Name	2-Naphthalenecarboxylicacid, 6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-
CAS No.	125316-60-1
Synonyms	2-Naphthalenecarboxylicacid, 6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-; O-Desmethyl Adapalene; CD 437; 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid AHPN; AHPN; ADAP-IME; 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid; Adapalene IMpurity F; AHPN, 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid; 6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-2-naphthalenecarboxylic; 2-naphthalenecarboxylicacid,6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphen; Apoptosis Activator VI, CD437; 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid; CD 437/AHPN; Apoptosis Activator VI, CD437/AHPN; CD437
Formula	C27H26O3
M.Wt	398.49354
SMILES	O=C(C1=CC=C2C=C(C3=CC=C(O)C(C4(C5)CC6CC5CC(C6)C4)=C3)C=CC2=C1)O
Purity	On request
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

DNA polymerase α / POLA1 · Literature evidence

Biological Activity

CD437 is a retinoid-like research compound with direct DNA polymerase α inhibition and antiproliferative activity in cancer-cell models. Wild-type POLA1 IC50: 22 nM. Resistant L700S and L764S variants gave IC50 values of 1.2 and 2.6 µM.

In Vitro

Endpoint	Model / conditions / source	Reported result
POLA1 inhibition	Recombinant DNA polymerase-α activity assay. [1], Fig. 3	Wild-type POLA1 IC50: 22 nM. Resistant L700S and L764S variants gave IC50 values of 1.2 and 2.6 µM.
Direct binding	POLA1 binding measurement. [1], Fig. 4	Kd was 67 ± 22 nM. This binding affinity is distinct from the enzymatic IC50.
DNA replication	HCT116 cells; CD437 1.5 µM for 2 h; BrdU incorporation. [1]	DNA synthesis was inhibited. Resistant clones required at least 15 µM for comparable inhibition.
Cell-death mechanism	Sensitive versus POLA1-mutant cells. [1]	S-phase effects and caspase-3-associated apoptosis supported a link between POLA1 inhibition and cytotoxicity.