DC Chemicals · Product datasheet

CD437 · DC10491

CD437 is a retinoid-like research compound with direct DNA polymerase α inhibition and antiproliferative activity in cancer-cell models.

ParameterValue
Chemical Name2-Naphthalenecarboxylicacid, 6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-
CAS No.125316-60-1
Synonyms2-Naphthalenecarboxylicacid, 6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-; O-Desmethyl Adapalene; CD 437; 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid AHPN; AHPN; ADAP-IME; 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid; Adapalene IMpurity F; AHPN, 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid; 6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-2-naphthalenecarboxylic; 2-naphthalenecarboxylicacid,6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphen; Apoptosis Activator VI, CD437; 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid; CD 437/AHPN; Apoptosis Activator VI, CD437/AHPN; CD437
FormulaC27H26O3
M.Wt398.49354
SMILESO=C(C1=CC=C2C=C(C3=CC=C(O)C(C4(C5)CC6CC5CC(C6)C4)=C3)C=CC2=C1)O
PurityOn request
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity summary

CD437 is a retinoid-like research compound with direct DNA polymerase α inhibition and antiproliferative activity in cancer-cell models.

View referenced In Vitro and In Vivo results on the product page

References

  1. Han T, et al. The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α. Nature chemical biology (2016).

Available packs

  • 100 mg · US$600
  • 250 mg · US$1,100
  • 1 g · US$2,100
  • 10 mM * 1 mL in DMSO · US$220
View product and biological activity →

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