Biological Activity & Performance
| Endpoint | Model / source | Reported finding |
|---|---|---|
| Enzyme inhibition | Biochemical assays; Fig. 1 / Supplementary Table 1 [1] | IC50: KAT6A 8 nM; KAT6B 28 nM. |
| Mechanism | Competition experiments [1] | Reversible inhibition competitive with acetyl-CoA. |
| Cell growth | E14.5 mouse embryonic fibroblasts; Fig. 2a [1] | Proliferation IC50 2.4 µM after 10 days; distinct from enzyme potency. |
| Cellular phenotype | Mouse embryonic fibroblasts; Fig. 2 [1] | Cell-cycle arrest and senescence depended on the INK4A/ARF pathway. |
| Animal model | KRASG12V-driven zebrafish liver cancer [1] | Reduced hepatocyte hyperproliferation and enhanced senescence. |
How to interpret the evidence
The mouse lymphoma efficacy in this paper belongs to WM-1119, not WM-8014. The older catalogue value of 55 nM reflects a different disclosure; values here follow the cited Nature study.