Epigenetics

WM-1119 is a KAT6A/KAT6B inhibitor for epigenetic and cellular-senescence research. The primary study reports binding selectivity, lymphoma-cell growth inhibition and suppression of lymphoma progression in mice.

WM-8014 is a KAT6A/KAT6B inhibitor for chromatin, cellular senescence and cancer research. Published work separates biochemical inhibition, fibroblast growth arrest and responses in a zebrafish liver cancer model.

MC3343 is a nonnucleoside DNMT inhibitor for epigenetic reprogramming, osteoblastic differentiation and osteosarcoma research.

OTS193320 is a SUV39H2 methyltransferase inhibitor for histone methylation, DNA-damage-response and cancer-cell research.

OTS186935 is a SUV39H2 inhibitor with published cellular and xenograft activity, used in histone-methylation and cancer research.

KL-1 is a small-molecule disruptor of the super elongation complex for transcriptional elongation and MYC-dependent cancer research.

KL-2 is a small-molecule disruptor of the super elongation complex for transcriptional elongation and MYC-dependent cancer research.

STM2457 is a catalytic METTL3 inhibitor for RNA methylation, leukemia-cell differentiation and cancer research.