Biological Activity
OTS186935 is a SUV39H2 inhibitor with published cellular and xenograft activity, used in histone-methylation and cancer research. OTS186935 IC50 was 6.49 nM.
In Vitro
| Endpoint | Model / conditions / source | Reported result |
|---|---|---|
| SUV39H2 inhibition | Biochemical assay. [1] | OTS186935 IC50 was 6.49 nM. |
| Cancer-cell growth | A549 lung-cancer cells. [1] | Reported growth IC50 was 0.67 µM, distinct from the biochemical value. |
In Vivo
| Endpoint | Model / conditions / source | Reported result |
|---|---|---|
| Breast-cancer xenograft | MDA-MB-231 xenografts; 10 mg/kg intravenously daily for 14 days; n=6. [1] | Tumor-growth inhibition was 42.6% (p=0.0006). |
| Lung-cancer xenograft | A549 xenografts; 25 mg/kg intravenously; n=3. [1] | Tumor-growth inhibition was 60.8%. This result belongs to OTS186935, not OTS193320. |
Interpretation
These are regimen- and model-specific tumor-growth inhibition values, not regression rates or evidence of general safety.
