Probes & Assay Reagents

Coelenterazine

CAS 55779-48-1

Coelenterazine is widely distributed among marine organisms which can produce bioluminescence by calcium-dependent oxidation mediated by the photoprotein aequorin.

(S)-PFI-2 HCl

CAS 1627607-88-8

Negative control of (R)-PFI 2 hydrochloride. Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC50 = 1 μM) compared to the active enantiomer.

CTX0294885

CAS 1439934-41-4

CTX-0294885 is a novel broad-spectrum kinase inhibitor. CTx-0294885 exhibits inhibitory activity against a broad range of kinases in vitro. Use of a quantitative proteomics approach confirmed the selectivity of CTx-0294885-bound beads for kinase enrichment.…

CycLuc1(Luciferase substrate)

CAS 1247879-16-8

CycLuc1 is a brain penetrant luciferase substrate.

Alkyne-a-dsbso

CAS 1704097-05-1

Novel Enrichable and MS-Cleavable Cross-linker to Define Protein-Protein Interactions by Mass Spectrometry

BF-227(E/Z)

CAS 845647-80-5

BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.

HYNIC-FAPI-04

HYNIC-FAPI-04 is a useful ligand for making [99mTc]Tc-HYNIC-FAPI-04. In vitro experiments, the results indicated that [99mTc]Tc-HYNIC-FAPI-04 showed binding properties, and inhibited the migration of tumor cells. The [99mTc]Tc-HYNIC-FAPI will be a promising…

kb-NB77-78

CAS 1350622-33-1

kb-NB77-78 is an analogue of CID797718, but shows no PKD inhibitory activity[1].

D-Luciferin (potassium salt)

CAS 115144-35-9

D-Luciferin potassium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects.

1-Methyl-7-nitroisatoic anhydride

CAS 73043-80-8

1-methyl-7-nitroisatoic anhydride is a reagent that detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity.

Fluoroclebopride

CAS 154540-49-5

Fluoroclebopride is useful chemical for PET image study. [18F]fluoroclebopride had been used for PET imaging of dopamine D2 receptors in monkeys

H-D-Phe-Pip-Arg-pNA hydrochloride（thrombinSubstrate, S-2238)

CAS 160192-34-7

H-D-Phe-Pip-Arg-pNA hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to…

TPEN

CAS 16858-02-9

TPEN is a specific cell-permeable heavy metal chelator.

GSK8573

CAS 1693766-04-9

GSK8573 (compound 23) is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy[1].

Dihydroethidium

CAS 104821-25-2

Dihydroethidium(Hydroethidine; PD-MY 003) is a superoxide indicator; exhibits blue-fluorescence in the cytosol until oxidized, where it intercalates within the cell's DNA, staining its nucleus a bright fluorescent red.

D-Luciferin

CAS 2591-17-5

D-luciferin is the natural substrate of luciferases that catalyze the production of light in bioluminescent insects.

S-2765(FXa substrate,Z-D-Arg-Gly-Arg-pNA Dihydrochloride)

CAS 113711-77-6

S-2765, which is specific to activated factor X (FXa), is a short peptide covalently bound to pNA (4-nitroaniline). When attacked by FXa, it releases a free pNA which could be detected by a spectrophotometer at 405 nm.S-2765 is mainly used in anti-FXa…

1-Methoxy PMS

CAS 65162-13-2

1-Methoxy PMS is stable electron-transport mediator between NAD(P)H and tetrazolium dyes.1-Methoxy PMS can induce active oxygen formation.

5-TAMRA

CAS 91809-66-4

The amine-reactive 5-TAMRA, SE and its conjugates yield bright, pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability.

AMPPD

CAS 122341-56-4

AMPPD, 1,2 - dioxo-cyclohexane derivatives, is a new biochemistry ultrasensitive alkaline phosphatase substrate.

CALCIUM IONOPHORE II

CAS 74267-27-9

N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) is a lipophilic ionophore that can be used in preparing calcium ion-selective electrode[1].

Furimazine

CAS 1374040-24-0

Furimazine is an imidazopyrazinone substrate. NanoLuc (Nluc) paired with Furimazine produced 2.5 million-fold brighter luminescence in mammalian cells relative to Oluc-19 with Coelenterazine.

PIH(Pyridoxal isonicotinoyl hydrazine)

CAS 737-86-0

Pyridoxal isonicotinoyl hydrazone (PIH) is a lipophilic, tridentate Fe-chelating agent that shows high Fe chelation efficacy[1].

MQAE

CAS 162558-52-3

MQAE is a fluorescent indicator that is quenched via collision with chloride, and is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells.

2-NBDG

CAS 186689-07-6

2-NBDG is a fluorescent indicator for direct glucose uptake measurement and also is an indicator of cell viability.

AP1867

CAS 195514-23-9

AP1867 is a synthetic FKBP12F36V-directed ligand.

LY2795050

CAS 1346133-08-1

LY2795050 is a novel selective κ-opioid Receptor (KOR) antagonist (IC50=0.72 nM) and has the potential as a PET tracer to image KOR in vivo.IC50 Value: 0.72 nM (κ-opioid Receptor); 25.8 nM (κ-opioid) [1]Target: κ-opioid Receptorin vitro: LY2795050 displays…

MRS1754

CAS 264622-58-4

MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats[1].

DOTATATE acetate

CAS 177943-89-4

DOTATATE acetate, a DOTA-conjugated peptide, and can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide therapy (PRRT)[1][2][3][4].

CH3OCO-D-CHA-Gly-Arg-pNA (Chromogenic Substrate Pefachrome FXa)

CAS 80895-10-9

CH3OCO-D-CHA-Gly-Arg-pNA acetate is a chromogenic substrate for factor Xa.

Methoxy-X04

CAS 863918-78-9

Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques.

4-Nitrophenylrhamnoside

CAS 18918-31-5

4-Nitrophenyl α-L-rhamnopyranoside is a chromogenic substrate for naringinase.

ML401 (CID73169083)

CAS 1597489-14-9

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1].

Alkyne tyramide

CAS 1694495-59-4

Alkyne tyramide is a clickable ascorbate peroxidase 2 (APEX2) probe. Alkyne tyramide substantially improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than APEX2 substrate biotin-phenol (BP). Alkyne tyramide also faci

DiZPK

CAS 1337883-32-5

DiZPK is a photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells.

Diphenylterazine (DTZ)

CAS 344940-63-2

Diphenylterazine is a bioluminescence agent.

Azidoacetic acid NHS ester

CAS 824426-32-6

Azidoacetic acid NHS ester is a compound containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of…

BRD7586

CAS 895460-70-5

BRD7586 is a cell-permeable small molecule inhibitor of SpCas9 with EC50 of 6.2 µM and 5.7 µM in the eGFP-disruption and HiBiT-knock-in assays, respectively. BRD7586 specifically engages SpCas9 but not Cas12a in cells and enhances SpCas9 specificity at…

Sulfo-Cy 5 NHS Ester

CAS 2230212-27-6

Sulfo-Cyanine 5 NHS Ester is a water soluble amine reactive red emitting fluorescent dye.Used for the labeling of various amine containing molecules in aqueous phase without use of any organic co-solvent. Useful for the labeling of proteins which denature in…

Biotin-aniline

CAS 769933-15-5

Biotin-aniline is a probe with substantially high reactivity towards RNA and DNA. Biotin-aniline emerges as more efficient probe for capturing subcellular transcriptome in living cells with high spatial specificity.

PSMA-617 Linker

CAS 1703768-74-4

Vipivotide tetraxetan Ligand-Linker Conjugate (PSMA-617 Ligand-Linker Conjugate) is composed of a linker and Glutamate-urea-Lysine, can be used to synthesize Vipivotide tetraxetan (PSMA-617). Glutamate-urea-Lysine is is the selective pharmacophore to bind to…

AkaLumine

CAS 1176235-08-7

AkaLumine is a luciferin analogue. The bioluminescence produced by AkaLumine in reactions with native firefly luciferase is in the near-infrared wavelength ranges (λmax=677?nm), and yields significantly increased target-detection sensitivity from deep tissues…

SBP-3264

CAS 2869148-13-8

SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency. SBP-3264 specifically inhibited the Hippo signaling pathway in cultured mammalian cells and possessed favorable pharmacokinetic and…

MC1

CAS 1018480-89-1

MC1 is a selective and potent COX-2 inhibitor, and its radiolabeled form, ¹¹CMC1, is a promising PET radiotracer for detecting COX-2 expression in vivo. Its ability to visualize COX-2 in neuroinflammation and other disease states makes it a valuable tool for…

MC1 Precursor

CAS 1018480-97-1

Precursor of MC1, is a vital component in the synthesis of MC1, a selective and potent COX-2 inhibitor. Radiolabeled MC1, ¹¹CMC1, serves as a promising PET radioligand for imaging COX-2 expression in vivo. Its high selectivity, combined with its ability to…

THK-5470(THK5470)

CAS 2410554-04-8

THK-5470(THK 5470), a monoamine oxidase-B (MAO-B) imaging probe, could be used for neurological diseases study. THK-5470 shows remarkably high binding affinity against MAO-B with an IC50 value of 4.2 nM, low binding affinity against tau with an IC50 value of…

PS-13 precursor 19

CAS 726196-75-4

PS-13 Precursor 19 is a critical intermediate in the synthesis of PS-13, a highly potent and selective COX-1 inhibitor. PS-13's exceptional selectivity for COX-1 over COX-2 makes it a promising compound for both therapeutic development and research…

PS13

CAS 524699-85-2

PS13 is a highly potent COX-1 inhibitor (IC50=1 nM) and 1,000 times more selective for COX-1 than COX-2 (7). In non-human primates, 11C-PS13 showed selective binding to COX-1 over COX-2 in most major organs including the spleen, gastrointestinal tract,…