Fluorescent and imaging probes, enzyme substrates and assay reagents.
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Other Research Tools (75) · Additional reagents, building blocks and specialized research tools.
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CAS 914805-33-7
Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire…
CAS 50-90-8
5-Chloro-2'-deoxyuridine, a thymine analog, is to study the potential of hypochlorous acid damage to DNA and DNA precursors.
CAS 106070-31-9
DCFH, also known as 2',7'-dichlorodihydrofluorescein, is a fluororescent agent. It is a key chemcial for the dichlorofluorescin (DCFH) oxidation assay.
CAS 2179052-10-7
Hydrofurimazine is a NanoLuc substrate whose enhanced aqueous solubility allows delivery of higher doses to mice. Hydrofurimazine enables sensitive bioluminescence imaging for either prolonged light production of high sensitivity.
CAS 82564-18-9
S-2222 is chromogenic substrate for factor Xa. When catalyzed by factor Xa, it releases a free pNA which could be detected by a spectrophotometer at 405 nm wavelength.Chromogenic substrate S-2222 can be used in many applications. For example, it is a key
Rhobo6 is a fluorescent glycan-binding probe optimized for live-cell imaging and in vivo tracking of glycoconjugates. It exhibits pH-dependent binding (pKa ~5-7), high photostability, and minimal cytotoxicity. Compatible with mammalian cells, zebrafish, plant…
CAS 2412089-96-2
Fluorofurimazine is an advanced furimazine derivative with enhanced aqueous solubility, allowing for greater signal output compared to furimazine in bioluminescence imaging. This compound supports higher substrate concentrations and delivers improved…
DesMEM AZD4694（AZD4694 Precursor 1）is the precursor of 18F AZD4694 for the synthesis of 18F AZD4694, an amyloid-β imaging ligand with high affinity for amyloid-β plaques.
CAS 3033659-13-8
Cephalofurimazine (CFz) is a NanoLuc substrate optimized for enhanced brain performance. When paired with Antares luciferase, it generates over 20 times more signal from the brain compared to the traditional combination of D-luciferin and firefly luciferase.
CAS 75350-46-8
Fluorescein-5-maleimide is a fluorescent thiol-reactive dye used to conjugate fluorescein to proteins (excitation: 494 nm, emission: 519 nm).
CAS 1283095-64-6
The Precursor of NOP-1A. (11)C-NOP-1A is a useful radioligand for quantifying NOP receptors in the monkey brain, and its radiation dose is similar to that of other (11)C-labeled ligands for neuroreceptors.
CAS 1283095-76-0
NOP-1A standard. 11C-NOP-1A is a new radioligand for thenociceptin/orphanin FQ peptide (NOP) receptor, with high affinity (Ki, 0.15 nM) and appropriate lipophilicity (measured logD, 3.4) for PET brain imaging. 11C-NOP-1A is the the first successful…
CAS 2758337-19-6
UAMC1110-NH2 is a derivative of UAMC1110 (SP-13786) with an aminobutoxy group, making it a useful intermediate for synthesizing UAMC1110 conjugates. UAMC1110 is a potent and selective FAP inhibitor with low nanomolar potency and high specificity over related…
CAS 268215-17-4
HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier.
CAS 74970-31-3
Cephalosporin C Na salt is used to study the effect of transpeptidase expression, binding, and inhibition on bacterial cell wall mucopeptide synthesis. Cephalosporin C has been used to determine activity during stopped-flow Fuorescence spectrometric…
CAS 86867-01-8
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also…
CAS 2250323-50-1
JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology[1].
CAS 942413-05-0
VKGILS-NH2 is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 has no effect on DNA synthesis in cells[1][2].
CAS 2050902-45-7
NHS-NH-(diethylamino)ethyl benzoate is a compound that can be used for N-glycan labeling.
CAS 2410554-19-5
THK-5475(THK5475) is a precursor of THK-5470, a monoamine oxidase-B(MAO-B) imaging probe, could be used for neurological diseases study (from patent EP2019-846498).
CAS 185835-97-6
SL-25.1188 is a reversible MAO-B inhibitor with high brain uptake and slow plasma metabolism, making it a promising candidate for treating Alzheimer's dementia and aiding in smoking cessation. Its ability to modulate neurotransmitter levels in the brain…
CAS 308818-13-5
ALS-I, an acid-Liable surfactant, is adopted for in-solution enzymatic digestions, can help to solubilize hydrophobic proteins. ALS-I is significantly enhanced peptide recovery for mass spectrometry (MS) mapping in the study of the proteomes of regenerating…
CAS 199745-67-0
Tex Red-X dye is an innovative alternative to Tex Red. A key difference lies in its chemical structure - it features an additional seven - atom aminocaproyl spacer ("X") between the fluorophore and the carboxyl group. This spacer plays a crucial role in…
CAS 459424-38-5
Fluorocholine chloride serves as a versatile biochemical tool for life science investigations, functioning both as an organic compound and biological marker in various research applications.
CAS 2173361-83-4
PI-2620 precursor is the precursor of PI2620. 18F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic feature of Alzheimer disease (AD) and other neurodegenerative disorders.
CAS 39450-01-6
Protease K is a nonspecific serine protease that is useful for general digestion of proteins. Protease K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures.
APS-3-77 is the negative binder of KSR2.
CAS 117620-77-6
3-Cyano-7-ethoxycoumarin is a fluorescent P450 substrate (excitation/emission wavelengths = 408/455 nm); metabolized to cyano-hydroxycoumarin.
CAS 2561494-77-5
UNC6934 is a potent and selective drug-like chemical probe to interrogate the function of NSD2-PWWP1 with Kd of 91 nM.UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 ±…
CAS 1114325-79-9
SL25.1188 Precursor is a key intermediate in the synthesis of SL25.1188, a reversible and selective MAO-B radioligand. The radiolabeled form, ¹¹CSL25.1188, is a promising PET imaging agent for studying MAO-B in the brain, with applications in…
Aca-Bio is a specialized chemical probe designed for the specific enrichment and detection of lysine acetoacetylation (Kacac). Its core architecture consists of a hydroxylamine group, a polyethylene glycol (PEG) linker, and a biotin tag. Functionally, the…
Ac-ATAD-AFC(Caspase-12 Substrate) is a fluorogenic substrate for caspase-12.
