UNC6934 chemical structure
Chemical structureResearch use only
CAT. NO. DC57111Featured

UNC6934

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TotalUS$850
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Product overview

Description & Application

UNC6934 is a potent and selective drug-like chemical probe to interrogate the function of NSD2-PWWP1 with Kd of 91 nM.UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 ± 0.23 microM. UNC7145, a closely-related control compound, with an iso-propyl group replacing a cyclo-propyl group, is inactive by SPR and NanoBret assays.

ParameterValue
Chemical Name2H -1,4-Benzoxazine-7-carboxamide, N -cyclopropyl-3,4-dihydro-3-oxo-N -[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- (ACI)
CAS No.2561494-77-5
SynonymsUNC6934;UNC-6934;UNC 6934
FormulaC24H21N5O4
M.Wt443.16
SMILESO=C(NC=1N=CN=CC1)C2=CC=C(C=C2)CN(C(=O)C3=CC=C4NC(=O)COC4=C3)C5CC5
Storage2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Biological Activity

UNC6934 is a potent and selective drug-like chemical probe to interrogate the function of NSD2-PWWP1 with Kd of 91 nM.UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 ± 0.23 microM. UNC7145, a closely-related control compound, with an iso-propyl group replacing a cyclo-propyl group, is inactive by SPR and NanoBret assays.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

Nature Chemical Biology, A chemical probe targeting the PWWP domain alters NSD2 nucleolar localizationMatthieu Schapira、Dalia Barsyte-Lovejoy、David Dilworth,Lindsey I. James

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

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