KPT-6566
CAS 881487-77-0
KPT-6566 is a covalent PIN1 inhibitor for cancer signaling research. Published studies connect PIN1 inhibition with oxidative stress, DNA damage, cancer-cell death and reduced lung colonization in mice.
DNA Damage, Repair & Cell Cycle
DNA replication, repair, mitosis and cell-cycle regulation.
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Kinases & Cell SignalingKinase inhibitors and modulators of intracellular signaling pathways.936 products →Epigenetics & Gene RegulationChromatin, transcription and epigenetic regulation.277 products →DNA Damage, Repair & Cell CycleDNA replication, repair, mitosis and cell-cycle regulation.228 products →Cell Death & AutophagyApoptosis, ferroptosis, necroptosis and autophagy research.117 products →Protein Degradation & ProteostasisPROTACs, molecular glues, ubiquitin systems, chaperones and proteostasis.173 products →Immunology & InflammationInnate and adaptive immunity, inflammatory pathways and immune signaling.297 products →NeuroscienceNeurotransmission, neural targets and neurological research.363 products →GPCRs & Receptor BiologyG-protein-coupled, nuclear and other ligand-binding receptors and their modulators.428 products →Ion Channels & TransportersIon channels, membrane transporters and pumps.196 products →Metabolism & EndocrinologyMetabolic enzymes, lipid and glucose metabolism and hormone signaling.404 products →Cardiovascular & HematologyVascular biology, coagulation, cardiac function, blood-pressure and hematology research.141 products →Anti-infectivesAntibacterial, antiviral, antifungal and antiparasitic research tools.202 products →Cancer ResearchCompounds with documented oncology research applications.530 products →ADCs & BioconjugationADC payloads, linkers, drug-linker conjugates and conjugation reagents.38 products →Probes & Assay ReagentsFluorescent and imaging probes, enzyme substrates and assay reagents.82 products →Natural ProductsNaturally occurring compounds for biological and chemical research.73 products →Cell Biology & Intracellular TransportCytoskeletal dynamics, endocytosis, vesicle trafficking, organelle function and cell differentiation.61 products →
Other Research Tools (75) · Additional reagents, building blocks and specialized research tools.
DNA Damage, Repair & Cell Cycle products
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CD437
CAS 125316-60-1
CD437 is a retinoid-like research compound with direct DNA polymerase α inhibition and antiproliferative activity in cancer-cell models.
OTS193320
CAS 2093401-33-1
OTS193320 is a SUV39H2 methyltransferase inhibitor for histone methylation, DNA-damage-response and cancer-cell research.
CB-002
CAS 61034-15-9
CB-002 (CB002) is a p53-pathway-restoring research compound studied in colorectal cancer cells and apoptosis signaling.
AZD1152
CAS 722543-31-9
AZD1152 is a pro-drug of Barasertib-hQPA, which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.
Fluzoparib
CAS 1358715-18-0
Fluzoparib (SHR-3162) is a novel, potent and orally available inhibitor of PARP; potently inhibited PARP1 enzyme activity and induced DNA double-strand breaks, G2/M arrest and apoptosis in homologous recombination repair (H)-deficient cells, Fluzoparib…
LY2835219 free base (Abemaciclib)
CAS 1231929-97-7
Abemaciclib (LY2835219) is a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.
Tenovin-3
CAS 1011301-27-1
Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.Target: p53in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to…
R1530
CAS 882531-87-5
R1530 is the multikinase inhibitor with potential antiangiogenesis and antineoplastic activities.R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial…
Epirubicin HCl (4'-epidoxorubicin)
CAS 56390-09-1
Epirubicin (hydrochloride) is a semisynthetic L-arabino derivative of doxorubicin, and an antineoplastic agent by inhibiting Topoisomerase.
AT7519 HCL
CAS 902135-91-5
AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.
Doxorubicin hydrochloride
CAS 25316-40-9
Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic for the treatment of multiple cancers. The possible mechanisms by which doxorubicin acts in the cancer cell are intercalation into DNA and disruption of topoisomerase-II-mediated DNA repair.
PJ34(free base)
CAS 344458-19-1
PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively.
TAK-960
CAS 1137868-52-0
TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively.
Talazoparib(BMN-673)
CAS 1207456-01-6
Talazoparib (BMN-673) is a highly potent PARP1/2 inhibitor with Kis of 1.2 nM and 0.87 nM, respectively.
BMH-21
CAS 896705-16-1
BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription; does not cause phosphorylation of H2AX.
PHA-848125(Milciclib)
CAS 802539-81-7
Milciclib (PHA-848125) is a potent, dual inhibitor of CDK and Tropomyosin receptor kinase (TRK), with IC50s of 45, 150, 160, 363, 398 nM and 53 nM for cyclin A/CDK2, cyclin H/CDK7, cyclin D1/CDK4, cyclin E/CDK2, cyclin B/CDK1 and TRKA, respectively.
Volasertib(BI6727)
CAS 755038-65-4
Volasertib is a highly potent Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM, as well as the two closely related kinases PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively.
Niraparib(MK4827) free base
CAS 1038915-60-4
Niraparib (MK-4827) is a highly potent PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively.
AZ3146
CAS 1124329-14-1
AZ3146 is a reasonably potent and selective Mps1 inhibitor with IC50 of 35 nM for Mps1Cat.
SNS-314 Mesylate
CAS 1146618-41-8
SNS-314 is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively.
AZD-7762
CAS 860352-01-8
AZD-7762 is a potent ATP-competitive checkpoint kinase (Chk) inhibitor in with an IC50 of 5 nM for Chk1.
JW55
CAS 664993-53-7
JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW 55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50s of 1.9 μM and 830 nM…
RO-3306
CAS 872573-93-8
Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively.
VE-822 (Berzosertib)
CAS 1232416-25-9
Berzosertib (VE-822) is an ATR inhibitor with a Ki value of less than 0.2 nM. It also inhibits ATM with a Ki of 34 nM.
SB1317(TG-02)
CAS 937270-47-8
SB1317 is a potent inhibitor of CDK2, JAK2, and FLT3 for the treatment of cancer, with IC50 of 13, 73, and 56 nM for CDK2, JAK2 and FLT3, respectively.
Ribociclib (LEE011)
CAS 1211441-98-3
LEE011, as dual CDK4/CDK6 inhibitor, significantly inhibits the growth of 12 of 17 neuroblastoma cell lines with mean IC50 of 307 nM. The growth inhibition of neuroblastoma cell lines is primarily cytostatic and is mediated by a G1 cell-cycle arrest and…
Prexasertib (LY2606368)
CAS 1234015-52-1
Prexasertib (LY2606368) is a potent, selective and ATP-competitive checkpoint kinase 1 (Chk1) inhibitor, with an IC50 and a Ki of <1 nM and 0.9 nM, respectively.
ELR-510444
CAS 1233948-35-0
ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines.ELR510444 is not a substrate for…
UPF 1069
CAS 1048371-03-4
UPF 1069 is a PARP inhibitor, with IC50s of 8 and 0.3 μM for PARP-1 and PARP-2, respectively.
PJ34 HCl
CAS 344458-15-7
PJ34 hydrochloride is an inhibitor of PARPl1/2 with IC50 of 110 nM and 86 nM, respectively.
AZD1080
CAS 612487-72-6
AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively.
Meisoindigo
CAS 97207-47-1
Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III), a derivative of Indigo naturalis, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).IC50 value:Target: apoptosis inducerin vitro: Meisoindigo inhibited the growth of…
DM1-SMe
CAS 138148-68-2
DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC).
SCR7 pyrazine
CAS 14892-97-8
SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine…
SNS-032(BMS-387032)
CAS 345627-80-7
SNS-032 (BMS-387032) is a selective inhibitor of?CDK2, CDK7, and CDK9 with?IC50s?of 38 nM, 62 nM and 4 nM, respectively.
Pyridostatin trifluoroacetate salt
CAS 1085412-37-8
Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM.
Palbociclib
CAS 571190-30-2
Palbociclib (PD 0332991) is a selective CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib is a drug for the treatment of ER-positive and HER2-negative breast cancer.
Palbociclib isethionate
CAS 827022-33-3
Palbociclib isethionate(PD-0332991 isethionate) is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
Triapine
CAS 143621-35-6
Triapine is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.
Monastrol
CAS 329689-23-8
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
MSC2530818
CAS 1883423-59-3
MSC2530818 is a potent, selective and orally available CDK8 inhibitor with an IC50 of 2.6 nM for CDK8.
LMP-744 hydrochloride
CAS 308246-57-3
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase (Top1) inhibitor with antitumor activity[1].
G007-LK
CAS 1380672-07-0
G007-LK is a potent and selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
RI-2
CAS 1417162-36-7
RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.
GSK1070916
CAS 942918-07-2
GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with Kis of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora A.
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