Anle138b
CAS 882697-00-9
Anle138b is an aggregation-modulating research compound studied in α-synucleinopathies. Published mouse data connect reduced oligomer burden with neuronal and motor outcomes.
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Other Research Tools (75) · Additional reagents, building blocks and specialized research tools.
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BD1063 dihydrochloride
CAS 206996-13-6
BD1063 dihydrochloride is a sigma-1 receptor antagonist used to study nociplastic pain and glial responses.
KML-29
CAS 1380424-42-9
KML-29 is a selective MAGL inhibitor used to investigate endocannabinoid metabolism, inflammatory pain and neuropathic pain.
Gefapixant(AF-219,MK-7264)
CAS 1015787-98-0
Gefapixant (AF-219, MK-7264) is a P2X3 antagonist for ATP-gated ion-channel and sensory signaling research.
PH-002
CAS 1311174-68-1
PH-002 is an ApoE4 structure-correcting research compound studied in human iPSC-derived neurons with Alzheimer-related phenotypes.
Soticlestat
CAS 1429505-03-2
Soticlestat is a cholesterol 24-hydroxylase inhibitor used in cholesterol turnover and neuronal-excitability research.
Tavapadon
CAS 1643489-24-0
Tavapadon (PF-06649751) is a non-catechol D1/D5 partial agonist for dopamine-receptor and motor-function research.
CLP257
CAS 1181081-71-9
CLP257 is a neuronal chloride-signaling research compound originally reported as a KCC2 enhancer. Subsequent work challenged direct KCC2 activation and reported GABAA receptor potentiation.
CR4056
CAS 1004997-71-0
CR4056 is an imidazoline-I2 ligand for pain signaling and monoaminergic research.
AWD 131-138(Imepitoin)
CAS 188116-07-6
AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.
Fenoldopam (mesylate)
CAS 67227-57-0
Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.Target: D1 ReceptorFenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam…
S1RA hydrochloride
CAS 1265917-14-3
S1RA Hcl(E-52862 Hcl) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
GNE-7915
CAS 1351761-44-8
GNE-7915 is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM.
Clemizole Hydrochloride
CAS 1163-36-6
Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM.
Emapunil(AC-5216)
CAS 226954-04-7
Emapunil(AC-5216;XBD-173) is a translocator protein[TSPO (18 kDa)] ligand.IC50 value:Target: TSPO ligandXBD173 enhanced gamma-aminobutyric acid-mediated neurotransmission and counteracted induced panic attacks in rodents in the absence of sedation and…
PF-2545920(MP-10)
CAS 898562-94-2
PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.PDE10A subcutaneously administrated at dose of 1 mg/kg elevates striatal cGMP about 3 fold in male CD-1 mice, while PDE10A subcutaneously…
LY2886721
CAS 1262036-50-9
LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease.IC50 value:Target: BACELY2886721 is a novel potent agent that is used to treat Alzheimer’s Disease in preclinical experiments. LY2886721 is under clinical study. A Safety Study of…
MDL 29951
CAS 130798-51-5
MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.
Lorcaserin Hydrochloride
CAS 846589-98-8
Lorcaserin (APD-356, trade name upon approval Belviq,expected trade name during development, Lorqess is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic. For the detailed information about the…
LY2811376
CAS 1194044-20-6
LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold…
L-685,458
CAS 292632-98-5
L-685458 is a potent inhibitor of Amyloid β-Protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested.IC50 value: 17 nMTarget: γ-secretasein vitro: L-685458 is a Notch inhibitor.…
AB928
CAS 2239273-34-6
A2aR/A2bR antagonist-1 is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist with immunomodulatory activity[1].
BX-471（ZK 811752）
CAS 217645-70-0
BX471 (ZK-811752) is a potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
PF-06869206
CAS 2227425-05-8
PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM.
NSI-189
CAS 1270138-40-3
NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.
Tranylcypromine HCl
CAS 1986-47-6
Tranylcypromine HCl is an inhibitor of monoamine oxidase (MAO) and prostacyclin synthase, potently suppresses the enzymatic activity of Lysine-Specific Demethylase 1 (LSD1) (IC50 <2 μM for BHC110/LSD1).
Clozapine N-oxide
CAS 34233-69-7
Clozapine N-oxide (CNO) is a major metabolite of the anti-psychotic drug clozapine. Clozapine N-oxide is a agonist for the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD) system.
Grapiprant
CAS 415903-37-6
Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
GBR 12935 dihydrochloride
CAS 67469-81-2
GBR 12935 2Hcl is a potent, and selective dopamine reuptake inhibitor.IC50 value: Target: dopamine reuptake inhibitorin vitro: The calculated Kd of [3H]GBR-12935 binding to CYP2D6 was 42.2 nM, indicating that GBR-12935 has a high affinity for CYP2D6. The…
Sal003
CAS 1164470-53-4
Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal with enhanced aqueous solubility.IC50 value:Target: eIF2α phosphatase inhibitorSal003 has been shown to prevent dephosphorylation of eIF-2α which has been shown to regulate…
LRRK2 inhibitor GSK2578215A
CAS 1285515-21-0
GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.GSK2578215A exhibits exceptionally high selectivity for LRRK2 across the kinome, substantially inhibits Ser910 and…
BMS-927711(Rimegepant)
CAS 1289023-67-1
Rimegepant (BMS-927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
MPTP (hydrochloride)
CAS 23007-85-4
MPTP hydrochloride is a brain penetrant dopamine neurotoxin, inducing Parkinson’s Disease.
Glabridin
CAS 59870-68-7
Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic,…
Fezolinetant
CAS 1629229-37-3
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
A-803467
CAS 944261-79-4
A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. IC50 value: 8 nMTarget: Nav1.8 sodium channelA 803467 dose-dependently reduces behavioral responses in a variety of…
Almorexant HCl (Act-078573)
CAS 913358-93-7
Almorexant Hcl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
ADX 47273
CAS 851881-60-2
ADX-47273 is a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
CZC-54252
CAS 1191911-27-9
CZC-54252 is a potent inhibitor of LRRK2 with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2 respectively
CIQ
CAS 486427-17-2
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. IC50 value: 2.7 μM (EC50, for NR2C) and 2.8 μM (EC50, NR2D)Target: NMDA receptorCIQ increases channel opening frequency of recombinant NR2Cor NR2D containing…
Felbamate
CAS 25451-15-4
Felbamate (FBM) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .Felbamate (marketed under the brand name Felbatol by MedPointe) is an anti-epileptic drug used in the treatment of…
Dexmedetomidine hydrochloride
CAS 145108-58-3
Dexmedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process.…
Belnacasan (VX-765)
CAS 273404-37-8
Belnacasan (VX-765) is an oral prodrug of VRT-043198, a potent and selective caspase-1 inhibitor with a Ki of 0.8 nM.
Tiagabine hydrochloride
CAS 145821-59-6
Tiagabine hydrochloride(NO328 hydrochloride) is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.Tiagabine had an early onset of effect, as shown by significant reduction from baseline in mean HAM-A total score compared with placebo at week 1…
Azeliragon（PF-04494700,TTP488）
CAS 603148-36-3
TTP488 is an antagonist at the Receptor for Advanced Glycation End products, is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD).
Isoxazole 9(ISX9)
CAS 832115-62-5
ISX-9 is a small molecule inducer of adult neural stem cell differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling…
BDP-12(Ampalex)
CAS 154235-83-3
Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
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