KML-29
CAS 1380424-42-9
KML-29 is a selective MAGL inhibitor used to investigate endocannabinoid metabolism, inflammatory pain and neuropathic pain.
Immunology & Inflammation
Innate and adaptive immunity, inflammatory pathways and immune signaling.
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Other Research Tools (75) · Additional reagents, building blocks and specialized research tools.
Immunology & Inflammation products
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RGX-104
CAS 610318-03-1
RGX-104 is an LXR agonist for studying myeloid-derived suppressor cells, ApoE signaling and tumor immune responses.
Elafibranor(GFT505)
CAS 923978-27-2
Elafibranor (GFT505) is a dual PPARα/δ agonist used in hepatic lipid metabolism, inflammation and fibrosis research.
LTX-401
CAS 1398051-86-9
LTX-401 is an amphipathic amino-acid derivative for cytolytic cell-death and local tumor-immunology research.
ABC 1183
CAS 1042735-18-1
ABC 1183 (ABC1183) is a dual GSK-3/CDK9 inhibitor for cancer-cell proliferation and inflammatory signaling research.
DO-264
CAS 2301866-59-9
DO-264 (DO264) is an ABHD12 inhibitor for lysophosphatidylserine metabolism and immune-lipid signaling research.
Praliciguat
CAS 1628730-49-3
Praliciguat is an sGC stimulator for nitric-oxide/cGMP signaling, renal inflammation and fibrosis research.
Tapinarof (Benvitimod; GSK2894512)
CAS 79338-84-4
Tapinarof (Benvitimod, GSK2894512) is an AHR-modulating compound for skin inflammation and keratinocyte research.
Adavivint
CAS 1467093-03-3
Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.
VGX-1027(GIT 27)
CAS 6501-72-0
VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.Administration of VGX-1027 to NOD mice with spontaneous or accelerated forms of…
WZ 811
CAS 55778-02-4
WZ811 is a potent CXCR4 antagonist, effectively inhibits TN14003 binding to CXCR4, with an EC50 of 0.3 nM.
ATB-346
CAS 1226895-20-0
ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. IC50 value: Target: COX-2 ATB-346 suppressed gastric prostaglandin E(2) synthesis as effectively as naproxen, but produced negligible damage in the stomach…
UNBS5162
CAS 956590-23-1
UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.
Y-320
CAS 288250-47-5
Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral…
Filgotinib(GLPG0634)
CAS 1206161-97-8
GLPG0634 is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
WS3
CAS 1421227-52-2
WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM(induced R7T1 proliferation).Protocol(Only for Reference) [1]In vivo efficacy studies in RIP-DTA mice:RIP-DTA mice were purchased from Jackson Laboratories and all aspects of…
AZD1480
CAS 935666-88-9
AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. IC50 value: 0.26 nM Target: JAK2 in vitro: AZD1480 demonstrated significant immunoregulatory effects by…
BMS-911543
CAS 1271022-90-2
BMS-911543 is a selective JAK2 inhibitor, with IC50s of 1.1 nM, less selective at JAK1, JAK3 and TYK2 (IC50, 75, 360, 66 nM, respectively).
PCI-32765 (Ibrutinib)
CAS 936563-96-1
Ibrutinib (PCI-32765) is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM.
BX-471（ZK 811752）
CAS 217645-70-0
BX471 (ZK-811752) is a potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
Momelotinib (CYT387,CYT-387)
CAS 1056634-68-4
Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50a of 11 nM and 18 nM,respectively. CYT387 shows much less activity against JAK3.
IT 901
CAS 1584121-99-2
IT-901 is an orally active and potent NF-κB subunit c-Rel inhibitor with an IC50 of 0.1 µM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively. IT-901, a bioactive naphthalenethiobarbiturate derivative, has the potential for human lymphoid tumors…
HPGDS-inhibitor-1
CAS 1033836-12-2
HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.IC50 Value: 0.7 nM [1]Target: HPGDSHPGDS inhibitor 1 was elected for further profiling based on its enzyme and cell potency. The…
Fostamatinib(R788)
CAS 901119-35-5
Fostamatinib (R788), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
Ruxolitinib (INCB018424)
CAS 941678-49-5
Ruxolitinib is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3.
RS-102895 hydrochloride
CAS 1173022-16-6
RS102895 hydrochloride is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.
Grapiprant
CAS 415903-37-6
Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
JAK2 Inhibitor V,Z3
CAS 195371-52-9
JAK2 Inhibitor V, Z3 is a cell-permeable pyridinylbutanone compound that inhibits both JAK2 and the active V167F mutant cellular autophosphorylation. JAK2 Inhibitor V, Z3 displays no effect against cellular Tyk 2 autophosphorylation in COS cells or SRC in…
TG101209
CAS 936091-14-4
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations.
Pirfenidone(AMR69)
CAS 53179-13-8
Pirfenidone is a drug used for the treatment of idiopathic pulmonary fibrosis. It inhibits FGFR, EGFR, PDGFR, TGF-β, thereby slowing tumor cell proliferation.
WHI-P154
CAS 211555-04-3
WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively.
BMS-986205(Linrodostat)
CAS 1923833-60-6
BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
Baricitinib (INCB28050, LY3009104)
CAS 1187594-09-7
Baricitinib is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.
Glabridin
CAS 59870-68-7
Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic,…
KIN1148
CAS 1428729-56-9
KIN1148, a small-molecule IRF3 agonist, is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy.
Montelukast Sodium
CAS 151767-02-1
Montelukast sodium is a potent, selective CysLT1 receptor antagonist.
Vidofludimus(4SC-101; SC12267)
CAS 717824-30-1
Vidofludimus(4SC-101; SC12267) is a novel immunosuppressive drug that inhibits DHODH; inhibits IL-17 secretion in vitro independently of effects on lymphocyte proliferation.
Belnacasan (VX-765)
CAS 273404-37-8
Belnacasan (VX-765) is an oral prodrug of VRT-043198, a potent and selective caspase-1 inhibitor with a Ki of 0.8 nM.
T-5224
CAS 530141-72-1
T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1. It also inhibits MMP3/13 with IC50s of 10 nM.
AVL-292
CAS 1202757-89-8
Spebrutinib (AVL-292; CC-292) is a covalent, orally active, and highly selective with an IC50 of 0.5 nM.
Oclacitinib maleate
CAS 1640292-55-2
Oclacitinib(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nM). IC50 value: 10 nM (JAK1) Target: JAKs in vitro: Oclacitinib inhibited the function of JAK1-dependent…
GW-3965 hydrochloride
CAS 405911-17-3
GW3965 hydrochloride is a potent and selective LXR agonist with EC50s of 190 and 30 nM for hLXRα and hLXRβ , respectively.
Bindarit
CAS 130641-38-2
Bindarit(AF-2838), a CCL2, CCL7 and CCL8 inhibitor, is an anti-inflammatory agent.
AMD3465
CAS 185991-07-5
AMD 3465 hexahydrobromide is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no…
Q-VD-Oph
CAS 1135695-98-5
Q-VD-OPha is a irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPha is able to cross the blood-brain barrier.
Teriflunomide(A-771726)
CAS 163451-81-8
Teriflunomide is the active metabolite of leflunomide, an approved therapy for rheumatoid arthritis. It inhibits pyrimidine synthesis and therefore potently decreases T cell and B cell proliferation.
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