DO-264

Name: DO-264
Brand: DC Chemicals
SKU: DC11464
Price: 800.0 USD

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Product overview

Description & Application

DO-264 (DO264) is an ABHD12 inhibitor for lysophosphatidylserine metabolism and immune-lipid signaling research.

Parameter	Value
Chemical Name	CID 134813646
CAS No.	2301866-59-9
Synonyms	CID 134813646; 1-(1-(3-Chloro-4-(2-chloro-4-(trifluoromethoxy)phenoxy)pyridin-2-yl)piperidin-4-yl)-3-(pyridin-3-yl)thiourea; 1-[1-[3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]pyridin-2-yl]piperidin-4-yl]-3-pyridin-3-ylthiourea; DO 264; GTPL10250; compound 46; DO264; DO-264
Formula	C23H20Cl2F3N5O2S
M.Wt	558.403411865234
SMILES	ClC1=C(C([H])=C([H])N=C1N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])N([H])C(N([H])C1=C([H])N=C([H])C([H])=C1[H])=S)OC1C([H])=C([H])C(=C([H])C=1Cl)OC(F)(F)F
Purity	On request
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

ABHD12 · Literature evidence

Biological Activity

DO-264 (DO264) is an ABHD12 inhibitor for lysophosphatidylserine metabolism and immune-lipid signaling research. DO-264 inhibited this lipid hydrolase and increased lyso-PS in primary human macrophages.

In Vitro

Endpoint	Model / conditions / source	Reported result
Target function	ABHD12-dependent lysophosphatidylserine metabolism. [1]	DO-264 inhibited this lipid hydrolase and increased lyso-PS in primary human macrophages.

In Vivo

Endpoint	Model / conditions / source	Reported result
Brain pharmacodynamics	Adult mice treated with DO-264. [1]	Brain lyso-PS increased, supporting in-vivo inhibition of ABHD12.
Auditory phenotype	Pharmacological treatment compared with genetic ABHD12 deletion. [1]	Adult drug-treated mice showed minimal auditory disturbance, unlike the knockout phenotype.
Inflammatory limitation	Immune-challenge experiments. [1]	ABHD12 inhibition was associated with heightened inflammation and severe lung pathology. These results preclude describing the compound as generally innocuous.