Cell Death & Autophagy

KPT-6566

CAS 881487-77-0

KPT-6566 is a covalent PIN1 inhibitor for cancer signaling research. Published studies connect PIN1 inhibition with oxidative stress, DNA damage, cancer-cell death and reduced lung colonization in mice.

SW076956

CAS 851717-83-4

SW076956 is an early BCL-2/Beclin 1 interaction inhibitor used in autophagy-modulation research.

LTX-401

CAS 1398051-86-9

LTX-401 is an amphipathic amino-acid derivative for cytolytic cell-death and local tumor-immunology research.

CB-002

CAS 61034-15-9

CB-002 (CB002) is a p53-pathway-restoring research compound studied in colorectal cancer cells and apoptosis signaling.

BL-AD008

BL-AD008 is an AMPK/ZIPK-directed activator investigated in cervical-cancer apoptosis research.

YM155

CAS 781661-94-7

YM-155 is a survivin inhibitor with an IC50 of 0.54 nM.

Tenovin-3

CAS 1011301-27-1

Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.Target: p53in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to…

Sabutoclax

CAS 1228108-65-3

Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.

Bioymifi

CAS 1420071-30-2

Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells.

Apoptosis Activator 2

CAS 79183-19-0

Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.

Lcl-161

CAS 1005342-46-0

LCL161 is a IAP inhibitor which inhibits XIAP in HEK293 cell and cIAP1 in MDA-MB-231 cell with IC50s of 35 and 0.4 nM, respectively.

pac-1

CAS 315183-21-2

PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.

NSC348884

CAS 81624-55-7

NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.

YM201636

CAS 371942-69-7

YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with IC50 of 3.3 μM.

HA-15

CAS 1609402-14-3

HA15 is a molecule that targets specifically BiP/GRP78/HSPA5target: BiP, GRP78, HSPA5 [1]In vitro: HA15 induces ER stress leading to cancer cell death. kills cancer cells by targeting BiP to increase ER stress, leading to melanoma cell death by concomitant…

Ferrostatin-1 (Fer-1)

CAS 347174-05-4

Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM.

Pifithrin-α (hydrobromide)

CAS 63208-82-2

Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis.

Meisoindigo

CAS 97207-47-1

Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III), a derivative of Indigo naturalis, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).IC50 value:Target: apoptosis inducerin vitro: Meisoindigo inhibited the growth of…

MHY1485

CAS 326914-06-1

MHY1485 is a cell-permeable mTOR activator. MHY1485 has an inhibitory effect on the autophagic process by inhibition of fusion between autophagosomes and lysosomes.

SCR7 pyrazine

CAS 14892-97-8

SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine…

APY0201

CAS 1232221-74-7

APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. APY0201 also inhibits IL-12/IL-23 production.

Belnacasan (VX-765)

CAS 273404-37-8

Belnacasan (VX-765) is an oral prodrug of VRT-043198, a potent and selective caspase-1 inhibitor with a Ki of 0.8 nM.

Z-VAD(OMe)-FMK

CAS 187389-52-2

Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor.

SBI-0206965

CAS 1884220-36-3

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2

Q-VD-Oph

CAS 1135695-98-5

Q-VD-OPha is a irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPha is able to cross the blood-brain barrier.

Venetoclax(ABT-199)

CAS 1257044-40-8

Venetoclax (ABT-199; GDC-0199) is a highly selective, orally bioavailable small-molecule inhibitor of Bcl-2, exhibiting sub-nanomolar binding affinity with a Ki of less than 0.01 nM. This compound has been demonstrated to induce autophagy, highlighting its…

tw-37

CAS 877877-35-5

TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.

Pifithrin-u

CAS 64984-31-2

Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.

Birinapant (TL32711)

CAS 1260251-31-7

Birinapant, a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kds of 45 nM and less than 1 nM, respectively.

Nutlin-3a

CAS 675576-98-4

Nutlin 3a is an active enantiomer of Nutlin-3, acts as a murine double minute (MDM2) antagonist that inhibits MDM2-p53 interactions and stabilizes the p53 protein, and thereby induces cell cycle arrest and apoptosis.

SBP-7455

CAS 1884222-74-5

SBP-7455 is an orally active dual-specific ULK1/2 autophagy inhibitor with improved binding affinity compared with SBI-0206965.

UMI-77

CAS 518303-20-3

UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

MX69

CAS 1005264-47-0

MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.

GSK4112

CAS 1216744-19-2

GSKGSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα

SU5614

CAS 1055412-47-9

(Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1].

Antibiotic 1037

CAS 606-58-6

Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage, with an IC50 of 80 nM. Toyocamycin (Vengicide) induces apoptosis. Toyocamycin (Vengicide) shows no…

A1155463

CAS 1235034-55-5

A-1155463 is a highly potent and selective BCL-XL inhibitor with an EC50 of 70 nM in Molt-4 cell.

WEHI-345

CAS 1354825-58-3

WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.

Apoptozole

CAS 1054543-47-3

Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.

BCL6 inhibitor(CID5721353)

CAS 301356-95-6

CID5721353 is an inhibitor of BCL6 with an IC50 value of 212 μM, which corresponds to a Ki of 147 μM.

SM-164

CAS 957135-43-2

SM-164 is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC50 value of 1.39 nM and functions as an extremely potent antagonist of XIAP.

Cyclovirobuxin D(Bebuxine)

CAS 860-79-7

Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR[1]. Cyclovirobuxine D inhibits cell proliferation of gastric…

GSK2982772

CAS 1622848-92-3

GSK2982772 is a potent and ATP competitive RIP1 inhibitor with an IC50 of 16 nM.

GSK2983559 active metabolite

CAS 1423186-80-4

GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.

ABT-263 (Navitoclax)

CAS 923564-51-6

Navitoclax (ABT-263) is a potent and oral Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM.

Emricasan

CAS 254750-02-2

Emricasan (PF 03491390) is an irreversible pan-caspase inhibitor.

Siramesine

CAS 147817-50-3

Siramesine(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agentsiramesine can induce rapid cell death in a number of…

Deguelin

CAS 522-17-8

Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor effect on several cancers; decrease levels of phosphorylated Akt. in vitro: Deguelin in a dose and time dependent manner inhibited the growth of MDA-MB-231,…