Cell Death & Autophagy

GSK583

CAS 1346547-00-9

GSK583 is a highly potent and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM.

YH239-EE

CAS 1364488-67-4

YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell…

GSK-872

CAS 1346546-69-7

GSK'872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM.

Lys05

CAS 1391426-22-4

Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth.

Apilimod

CAS 541550-19-0

Apilimod is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively.

NSC 185058

CAS 39122-38-8

NSC 185058 is an ATG4B inhibitor. NSC185058 markedly attenuates autophagic activity[1].

GSK840

CAS 2361146-30-5

Novel potent and selective RIP3 kinase inhibitor

DMXAA

CAS 117570-53-3

Vadimezan (ASA-404; DMXAA), the vascular disrupting agent, is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines.

Auten-99

CAS 1049780-58-6

Auten-99 is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14), acrossing the blood-brain barrier and exerting potent neuroprotective effects.

Bax inhibitor peptide V5

CAS 579492-81-2

Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.

NVP-CGM097 (CGM-097)

CAS 1313363-54-0

NVP-CGM097 is a potent and selective MDM2 inhibitor with IC50 of 1.7±0.1 nM for hMDM2.

S55746 (BLC201)

CAS 1448584-12-0

S55746 is an orally active, selective and potent BCL-2 inhibitor, with a Ki of 1.3 nM.

UAMC-3203 hydrochloride

CAS 2271358-65-5

UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM[1].

DC661

CAS 1872387-43-3

DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity[1].

Curcumin analog C1(TFEB activator 1 )

CAS 39777-61-2

TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and…

PRIMA-1MET(APR-246)

CAS 5291-32-7

PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.

ULK-101

CAS 2443816-45-1

ULK-101 (ULK101) is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM, inhibits ULK2 with IC50 of 30 nM; reduces Ser15 phosphorylation in a concentration-dependent manner in cell-based assay (EC50=390 nM), which is more potent than…

8-Hydroxy-efavirenz

CAS 205754-33-2

8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz.8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary…

GSK963

CAS 2049868-46-2

GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].

ASTX660(Tolinapant）

CAS 1799328-86-1

ASTX660 is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP).

Supinoxin

CAS 888478-45-3

Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase (P-p68) and a potent first-in-class anti-cancer agent. Supinoxin interacts with Y593 phosphorylated-p68 and attenuates the nuclear shuttling of β-catenin. Supinoxin induces…

NVP-HDM201(Siremadlin )

CAS 1448867-41-1

NVP-HDM201 (HDM201) is a potent and highly specific MDM-2/p53 inhibitor currently under phase I clinical trial.

DIM-C-pPhOH(CDIM8)

CAS 151358-47-3

DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O…

HBX41108

CAS 924296-39-9

Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in…

TVB-3166

CAS 1533438-83-3

TVB-3166 is an orally-available, reversible, and selective fatty acid synthase (FASN) inhibitor with IC50s of 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor…

BRD-810

CAS 2329719-65-3

BRD-810 is a potent and selective MCL1 inhibitor with Kd of 0.3 nM (SPR) and IC50 of 0.4 nM (MCL1-Noxa HTRF), respectively. BRD-810 is a rapidly cleared inhibitor of MCL1 that has robust antitumor efficacy in hematological and solid tumor cancer models.

Imidazole ketone erastin（IKE）

CAS 1801530-11-9

Imidazole ketone erastin (IKE) s a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system Xc- and an activator of ferroptosis.

FX1

CAS 1426138-42-2

FX1 is a potent and specific BCL6 inhibitor, with an IC50 of around 35 μM.

A-1331852

CAS 1430844-80-6

A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.

Necrostatin-1

CAS 4311-88-0

Necrostatin-1 is a potent, selective and cell-permeable necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. It acts by inhibiting the death domain kinase RIP (RIP1) in the necroptosis pathway.

Bim-IN-1

Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity.

Cl-amidine hydrochloride

CAS 1373232-26-8

In Vitro Cl-amidine is a peptidylarginine deminase (PAD) inhibitor, with an IC50 of 5.9±0.3 μM for PAD4 and Cl-amidine is a bioavailable haloacetamidine-based compound that inhibits all the active PAD isozymes with near equal potency (kinact/KI=13,000…

RSL3

CAS 1219810-16-8

RSL3 (1S,3R-) is a glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 10 μM in cellular assay.

Hydrazinocurcumin

CAS 131068-23-0

Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets;…

SB02024

CAS 2126737-28-6

SB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, >1000 times selective towards other PI3K isoenzymes; SB02024 is also highly selective at 1 uM in the DiscoveRx…

CIL56(CA3)

CAS 300802-28-2

CIL56 is a potent and selective ferroptosis inducer. Ferroptosis is an iron-dependent form of regulated cell death (RCD).

NSC729477

CAS 229971-81-7

Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor…

Elesclomol (STA-4783)

CAS 488832-69-5

Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis.

Erastin

CAS 571203-78-6

Erastin is a ferroptosis activator.

GSDMD agonist DMB (C-185)

CAS 281209-71-0

DMB(C-185) is a direct and selective GSDMD agonist that activates GSDMD pore formation and pyroptosis without cleaving GSDMD. DMB treatment synergizes with anti-PD-1 and does not alter circulating proinflammatory cytokine or leukocyte numbers or cause weight…

BO-264

CAS 2408648-20-2

BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint…

BTSA1.2

CAS 2254256-66-9

BTSA1.2 is a rationalized BTSA1 analog with improved binding to BAX, cellular cytotoxicity, and better toleratence in vivo. Combination of BTSA1.2 with Navitoclax demonstrates synergistic efficacy in apoptosis-resistant cancer cells, xenografts, and…

COTI-2

CAS 1039455-84-9

COTI-2 is a small molecule candidate anti-cancer drug which can convert mutant p53 to wild-type conformation.

AC-003

CAS 2258671-03-1

AC-003 is a novel, orally administered small-molecule inhibitor targeting receptor-interacting protein kinase 1 (RIPK1), demonstrating therapeutic potential for the treatment of idiopathic pulmonary fibrosis (IPF).

NSC319726

CAS 71555-25-4

NSC319726 is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells.in vitro: For NSC319726, the effect was even greater as the IC50 for the 175 mutant was 8 nM…

NH-23-C2

NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S).HCT116 cells…

NVS-ZP7-4

CAS 2349367-89-9

NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of the compound photoaffinity labeled ZIP7…

Hypocrellin B

CAS 123940-54-5

Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial…