Laropiprant
CAS 571170-77-9
Laropiprant is a DP1 receptor antagonist for prostanoid signaling and platelet-function research. Its effects on platelet activation vary with agonist and concentration.
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Other Research Tools (75) · Additional reagents, building blocks and specialized research tools.
GPCRs & Receptor Biology products
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BD1063 dihydrochloride
CAS 206996-13-6
BD1063 dihydrochloride is a sigma-1 receptor antagonist used to study nociplastic pain and glial responses.
JTE-013
CAS 383150-41-2
JTE-013 is an S1PR2 antagonist used in sphingosine-1-phosphate signaling, mitochondrial dynamics and fibrosis research.
RGX-104
CAS 610318-03-1
RGX-104 is an LXR agonist for studying myeloid-derived suppressor cells, ApoE signaling and tumor immune responses.
Elafibranor(GFT505)
CAS 923978-27-2
Elafibranor (GFT505) is a dual PPARα/δ agonist used in hepatic lipid metabolism, inflammation and fibrosis research.
TAK-615
CAS 1664335-55-0
TAK-615 is an LPA1 negative allosteric modulator for receptor signaling and fibrosis-related pathway research.
Omidenepag
CAS 1187451-41-7
Omidenepag is an EP2 receptor agonist for prostanoid signaling and ocular-cell research.
MRL871
CAS 1392809-08-3
MRL871 (MRL-871) is an allosteric RORγt ligand used in nuclear-receptor research. Independent work also identified PPARγ partial agonism.
Tavapadon
CAS 1643489-24-0
Tavapadon (PF-06649751) is a non-catechol D1/D5 partial agonist for dopamine-receptor and motor-function research.
Tapinarof (Benvitimod; GSK2894512)
CAS 79338-84-4
Tapinarof (Benvitimod, GSK2894512) is an AHR-modulating compound for skin inflammation and keratinocyte research.
Calcitriol (Rocaltrol)
CAS 32222-06-3
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
BMS-833923 (XL-139)
CAS 1059734-66-5
BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.BMS-833923 inhibits the sonic hedgehog…
Seladelpar
CAS 851528-79-5
Seladelpar is an orally active, potent (50% effect concentration EC50 2 nM), and specific PPAR-δ agonist.
Fenoldopam (mesylate)
CAS 67227-57-0
Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.Target: D1 ReceptorFenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam…
Ki16425
CAS 355025-24-0
Ki16425 is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively.
S1RA hydrochloride
CAS 1265917-14-3
S1RA Hcl(E-52862 Hcl) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
DIM-C-pPhOCH3(C-DIM5)
CAS 33985-68-1
DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.
MBX-2982
CAS 1037792-44-1
MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist.
WZ 811
CAS 55778-02-4
WZ811 is a potent CXCR4 antagonist, effectively inhibits TN14003 binding to CXCR4, with an EC50 of 0.3 nM.
Palovarotene(R 667)
CAS 410528-02-8
Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.
ALG1001 (Risuteganib)
CAS 1307293-62-4
ALG1001 (Risuteganib, ALG-1001) is a first-in-class, RGD class oligopeptide that inhibits integrin receptors (αvβ3, αvβ5, and α5β1) associated with angiogenesis; ALG1001 inhibits an integrin-mediated pathway of the vitreoretinal interface, connecting the…
SSR-240612 HCl
CAS 464930-42-5
SSR240612 is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist, with Kis of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of…
LDE225 Diphosphate
CAS 1218778-77-8
Erismodegib diphosphate (LDE225 diphosphate) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
AC 55541
CAS 916170-19-9
AC-55541 is a novel small-molecule protease-activated receptor 2(PAR2) agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.
Glasdegib(PF-04449913)
CAS 1095173-27-5
Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.
StemRegenin 1(SR-1)
CAS 1227633-49-9
StemRegenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC50 of 127 nM.
AB928
CAS 2239273-34-6
A2aR/A2bR antagonist-1 is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist with immunomodulatory activity[1].
BX-471（ZK 811752）
CAS 217645-70-0
BX471 (ZK-811752) is a potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
ML 161
CAS 423735-93-7
Parmodulin 2 (ML161),a probe, is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM. Parmodulin 2 inhibits platelet aggregation induced by a PAR1 peptide agonist or by thrombin and has shown cytoprotective effects[1, 2].
Clozapine N-oxide
CAS 34233-69-7
Clozapine N-oxide (CNO) is a major metabolite of the anti-psychotic drug clozapine. Clozapine N-oxide is a agonist for the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD) system.
RS-102895 hydrochloride
CAS 1173022-16-6
RS102895 hydrochloride is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.
Grapiprant
CAS 415903-37-6
Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
CCDC(TGR5-Receptor-Agonist)
CAS 1197300-24-5
TGR5 Receptor Agonist, a potent TGR5(GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).
Fenretinide (4-HPR)
CAS 65646-68-6
Fenretinide is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
Vismodegib (GDC-0449)
CAS 879085-55-9
Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. It also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively.
BMS-927711(Rimegepant)
CAS 1289023-67-1
Rimegepant (BMS-927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
AM580
CAS 102121-60-8
AM580 is a selective RARα agonist with IC50 and EC50 of 8 nM and 0.36 nM, respectively.
GSK2033
CAS 1221277-90-2
GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively.
GW-9508
CAS 885101-89-3
GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.IC50 value: 7.32 (pEC50) [1]Target: GPR40GW9508 is shown to be at least 100-fold…
MGL-3196(Resmetirom)
CAS 920509-32-6
MGL-3196 is a highly selective thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.21 μM.
Glabridin
CAS 59870-68-7
Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic,…
AdipoRon
CAS 924416-43-3
AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with Kds of 1.8 and 3.1 μM, respectively.
Fezolinetant
CAS 1629229-37-3
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
Montelukast Sodium
CAS 151767-02-1
Montelukast sodium is a potent, selective CysLT1 receptor antagonist.
Almorexant HCl (Act-078573)
CAS 913358-93-7
Almorexant Hcl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
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