ND-646
CAS 1434639-57-2
ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.
Metabolism & Endocrinology
Metabolic enzymes, lipid and glucose metabolism and hormone signaling.
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Other Research Tools (75) · Additional reagents, building blocks and specialized research tools.
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UK-5099
CAS 56396-35-1
UK-5099 is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 ihibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.
SR9243
CAS 1613028-81-1
SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction.
Etelcalcetide Hydrochloride(AMG-416)
CAS 1334237-71-6
Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis…
Ganirelix acetate
CAS 129311-55-3
Ganirelix acetate is an antagonist of GnRH that competitively antagonizes the gonadotropic GnRH receptor, thereby mutating the pathway and causing rapid and reversible inhibition of gonadotropin (luteinizing hormone LH and follicle stimulating hormone FSH)…
SW033291
CAS 459147-39-8
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
WAY-200070
CAS 440122-66-7
WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM.
SRT1720 HCl
CAS 1001645-58-4
SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities on SIRT2 and SIRT3 with EC1.5s of 37 μM and 300 μM, respectively.
BRD7552
CAS 1137359-47-7
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.
AVN944
CAS 297730-17-7
AVN-944(VX-944) is a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2
Miglustat hydrochloride
CAS 210110-90-0
Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).Miglustat is an inhibitor of the ceramide-specific glycosyltransferase, which catalyzes the first step of glycosphingolipid biosynthesis and…
Migalastat hydrochloride
CAS 75172-81-5
Migalastat hydrochloride (1-Deoxygalactonojirimycin hydrochloride) is a potent and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC50 of 0.04 μM for human α-Gal A.
CYM-5541 (ML249)
CAS 945128-26-7
CYM-5541 (ML249) is an selective and allosteric S1P3 receptor agonist with an EC50 between 72 and 132 nM.
Nolatrexed dihydrochloride (AG-337)
CAS 152946-68-4
Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has…
Calcifediol
CAS 19356-17-3
Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).
MK-0941
CAS 1137916-97-2
MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in the treatment of type 2 diabetes[1].
Thiamet G
CAS 1009816-48-1
Thiamet-G is a potent and selective inhibitor of OGA, which acts to remove O-GlcNAc from modified proteins, with Ki of 20 nM for human OGA.
Rosuvastatin Calcium
CAS 147098-20-2
Rosuvastatin Calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.
Carbetocin
CAS 37025-55-1
Carbetocin (Lonactene; Duratocin) is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth; an agonist at peripheral oxytocin receptors.
Atorvastatin calcium
CAS 134523-03-8
For the detailed information of Atorvastatin Calcium, the solubility of Atorvastatin Calcium in water, the solubility of Atorvastatin Calcium in DMSO, the solubility of Atorvastatin Calcium in PBS buffer, the animal experiment（test） (test) of Atorvastatin…
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