Dabigatran etexilate mesylate
CAS 872728-81-9
Dabigatran etexilate mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.
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Ranolazine (Ranexa)
CAS 95635-55-5
Ranolazine is an antianginal medication.Target: Sodium ChannelRanolazine is believed to have its effects via altering the transcellular late sodium current. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the…
Senicapoc
CAS 289656-45-7
Senicapoc (ICA-17043) is a potent and selective Gardos channel blocker with IC50 value of 11 nM. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
BIBR 953(Dabigatran)
CAS 211914-51-1
Dabigatran(BIB-953; BIBR 953ZW) is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.
NS309
CAS 18711-16-5
NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.IC50 value: Ca2+-activated K+ channelTarget:
Tirofiban (hydrochloride monohydrate)
CAS 150915-40-5
Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonistTirofiban hydrochloride monohydrate blocks platelet aggregation and thrombus formation. Tirofiban is an antithrombotic used in the…
1-EBIO
CAS 10045-45-1
1-EBIO is an Epithelial KCa channel activator. Promotes ESC differentiation into cardiomyocytes.
ML365
CAS 947914-18-3
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3) with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay).ML365 possesses more than 60-fold selectivity for inhibition of TASK1 over a closely-related,…
Macitentan (Actelion-1,ACT-064992)
CAS 441798-33-0
Macitentan is an orally active, non-peptide endothelin receptor antagonist for the treatment of idiopathic pulmonary fibrosis and pulmonary arterial hypertension.
Sematilide hydrochloride
CAS 101526-62-9
Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1].
Atipamezole
CAS 104054-27-5
Atipamezole is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.
Israpafant
CAS 117279-73-9
Israpafant (Y24180) is a specific antagonist of PAF receptor that inhibits PAF-induced rabbit platelet aggregation in vitro (IC50=3.84 nM), with little effect on adenosine diphosphate- or arachidonic acid-induced aggregation.
Riociguat (BAY 63-2521)
CAS 625115-55-1
Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
Timolol Maleate
CAS 26921-17-5
(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).(S)-Timolol, 50% bioavailability following oral administration. Does not cross the blood brain…
VTP-27999
CAS 942142-51-0
VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
Lercanidipine HCl
CAS 132866-11-6
Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.Lercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely…
Azilsartan medoxomil
CAS 863031-21-4
Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
NUCC-0200590
CAS 1060461-67-7
NUCC-0200590 is a small-molecule inhibitor of the TRIP8b-HCN interaction with IC50 of 7.0 uM in AlphaScreen assays, effectively disrupts the TRIP8b-HCN interaction in vitro and in vivo.
Pirmenol hydrochloride
CAS 61477-94-9
Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.
DMX-5804
CAS 2306178-56-1
DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces…
Nimodipine
CAS 66085-59-4
Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.Nimodipine is main use is in the prevention of…
Indacaterol
CAS 312753-06-3
Indacaterol is a potent, orally administered ultra-long-acting β2 adrenergic receptor (ADRB2) agonist, widely recognized for its therapeutic potential in respiratory and cardiovascular conditions. By selectively activating ADRB2, indacaterol not only enhances…
Desmopressin (Acetate)
CAS 62288-83-9
Desmopressin(DDAVP) acetate is the synthetic analogue of the antidiuretic hormone arginine vasopressin. IC50 Value:Target: Vasopressin ReceptorThe antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal…
Chlorpromazine HCl
CAS 69-09-0
Chlorpromazine Hydrochloride is an antagonist of the dopamine D2, 5HT2A, potassium channel andsodium channel. Chlorpromazine binds with D2 and 5HT2A with Kis of 363 nM and 8.3 nM, respectively.
MLS 0263839
CAS 716375-92-7
MLS 0263839 is a potent, specific inhibitor of the phosphatase PHOSPHO1 with IC50 of 0.14 uM, shows minimal cross-inhibition of TNAP and no inhibition of ENPP1 activity; suppresses vascular smooth muscle cell calcification in cimbined with MLS 0038949.
Losartan Potassium
CAS 124750-99-8
Losartan (potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.
ML-T531
CAS 791127-70-3
ML-T531 is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM; exhibits no potentiation for KCNQ1 and KCNE1, and no noticeable effects on other cardiac channels including Cav1.2, Kir2.1, Nav1.5, and Kv4.3; significantly…
Ezetimibe (Zetia)
CAS 163222-33-1
Ezetimibe (SCH 58235) is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor.
Nattokinase
CAS 133876-92-3
Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases[1].
SP-8356
CAS 1454885-45-0
SP-8356, an anti-inflammatory synthetic verbenone derivative, is a potent, orally active cluster of differentiation 147 (CD147) inhibitor. SP-8356 inhibits CD147-cyclophilin A (CypA) interaction and reduces MMP-9 activity. SP-8356 exerts anti-breast cancer…
Betanin
CAS 7659-95-2
In Vitro Betanin is a representative constituent of red beetroot betacyanins, could inhibit peroxynitrite (ONOO-), with an IC50 of 19.2 μM. Betanin also has anti-inflammatory, anti-proliferative effects, nephroprotective activity, cardioprotective activity,…
Simvastatin (Zocor)
CAS 79902-63-9
Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
VU0606170
CAS 879054-55-4
VU 0606170 (also referred to as VU0606170) is a selective inhibitor of the sodium-activated potassium channel KNa1.1, also known as Slack or Slo2.2. This compound has shown specificity for Slack channels over other related potassium channels, making it a…
Losartan Carboxylic Acid
CAS 124750-92-1
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks…
Nepicastat HCl (SYN-117)
CAS 170151-24-3
Nepicastat Hcl(SYN117 Hcl; RS-25560-197 Hcl) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively.Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of dopamine to…
Vanoxerine dihydrochloride
CAS 67469-78-7
Vanoxerine dihydrochloride is a potent and selective dopamine reuptake inhibitor.
Ibutilide fumarate
CAS 122647-32-9
Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm.Ibutilide is the first 'pure' class III antiarrhythmic drug to become available.…
LY-3000328
CAS 1373215-15-6
LY-3000328 is a potent, highly selective cathepsin S inhibitor with IC50 of 7.7 nM; dispalys >500-fold selectivity over cathepsin L, cathepsint K, cathepsin B, and cathepsin V; shows efficacy in a CaCl2-induced AAA (Abdominal Aortic Aneurysm) in vivo…
Rosuvastatin Calcium
CAS 147098-20-2
Rosuvastatin Calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.
Org 34167 hydrochloride
CAS 198966-49-3
Org 34167 HCl salt is a broad-spectrum inhibitor of HCN channels with IC50 of 23.4, 8.2 and 9.2 uM for HCN1, HCN2 and HCN4 channels, respectively, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation.
Bisoprolol fumarate (2:1)
CAS 104344-23-2
Bisoprolol, on beta 1-adrenoceptor pBisoprolol is a selective type β1 adrenergic receptor blocker.Approved: July 31, 1992Bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced…
Atorvastatin calcium
CAS 134523-03-8
For the detailed information of Atorvastatin Calcium, the solubility of Atorvastatin Calcium in water, the solubility of Atorvastatin Calcium in DMSO, the solubility of Atorvastatin Calcium in PBS buffer, the animal experiment（test） (test) of Atorvastatin…
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