Timolol Maleate chemical structure
Chemical structureResearch use only
CAT. NO. DC9137Featured

Timolol Maleate

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TotalUS$300
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Product overview

Description & Application

(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).(S)-Timolol, 50% bioavailability following oral administration. Does not cross the blood brain barrier. Timolol maleate does appear to have some local anesthetic properties in human cornea after chronic use by susceptible individuals.

ParameterValue
Chemical Name(S)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol maleate
CAS No.26921-17-5
SynonymsL 714,465; L-714,465; L714,465; MK 950; MK-950; MK950; Optimol; Timacar; Timolol maleate; brand name: Betimol, Blocadren, Istalol, Timoptic, Timoptic-XE, Timoptic OcuDose.
FormulaC17H28N4O7S
M.Wt432.492
SMILESC1(=NSN=C1OC[C@@H](O)CNC(C)(C)C)N1CCOCC1.O=C(O)/C=C\C(O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).(S)-Timolol, 50% bioavailability following oral administration. Does not cross the blood brain barrier. Timolol maleate does appear to have some local anesthetic properties in human cornea after chronic use by susceptible individuals.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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