LY-2940680(Taladegib)
CAS 1258861-20-9
Taladegib (LY2940680) is an antagonist of the smoothened receptor.
Kinases & Cell Signaling
Kinase inhibitors and modulators of intracellular signaling pathways.
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Other Research Tools (75) · Additional reagents, building blocks and specialized research tools.
Kinases & Cell Signaling products
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BI-78D3
CAS 883065-90-5
BI-78D3 functions as a substrate competitive inhibitor of JNK, inhibit the JNK kinase activity (IC50=280 nM).
Deguelin
CAS 522-17-8
Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor effect on several cancers; decrease levels of phosphorylated Akt. in vitro: Deguelin in a dose and time dependent manner inhibited the growth of MDA-MB-231,…
AG-18
CAS 118409-57-7
Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.
IKK-16(free base)
CAS 873225-46-8
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM.
SC-66
CAS 871361-88-5
SC66 is a novel Akt inhibitor, reduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in hepatocellular carcinoma (HCC) cells.
GSK583
CAS 1346547-00-9
GSK583 is a highly potent and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM.
Tivantinib (ARQ 197)
CAS 905854-02-6
Tivantinib is a novel and highly selective c-Met tyrosine kinase inhibitor with Ki of 355 nM.
TP0463518
CAS 1558021-37-6
TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1].
YH239-EE
CAS 1364488-67-4
YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell…
AMG 925
CAS 1401033-86-0
AMG 925 is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively.
BLU-782
CAS 2141955-96-4
ALK2-IN-1 is a activin receptor-like kinase-2 (ALK2) inhibitor extracted from patent WO2017181117A1, Compound 876, has an IC50 of <10 nM[1].
THZ531
CAS 1702809-17-3
THZ531 is a covalent inhibitor of both CDK12 and CDK13 with IC50s of 158 nM and 69 nM, respectively.
Lazertinib
CAS 1903008-80-9
Lazertinib is a potent, highly mutant-selective, blood-brain barrier permeable, orally available and irreversible third-generation EGFR tyrosine kinase inhibitor, and can be used in the research of non-small cell lung cancer.
RMC-9805（Zoldonrasib）
CAS 2922732-54-3
RMC-9805 is a first-in-class, mutant-selective, covalent and orally bioavailable KRAS-G12D(ON) inhibitor. RMC-9805 exhibits direct anti-tumor effects and indirectly transformed the TME through inhibition of cancer cell-intrinsic KRAS-G12D oncogenic signaling.
SMAP
CAS 1809427-18-6
SMAP (DT-061, DT061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth; acts by binding to the PP2A Aα scaffold subunit to drive conformational changes in PP2A; inhibits the growth of KRAS-mutant lung cancers in…
Losmapimod
CAS 585543-15-3
Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively.
UU-T02
CAS 1500080-17-0
UU-T02 is a novel potent, selective small-molecule inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM; displays 63-fold and 175-fold selectivity over β-catenin/E-cadherin and β-catenin/APC interactions, respectively.
Bafetinib (INNO-406)
CAS 859212-16-1
Bafetinib is a Lyn and Bcr-Abl tyrosine kinase inhibitor with potential antineoplastic activity.
CL-387785
CAS 194423-06-8
CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.
AT9283
CAS 896466-04-9
AT9283 is a multitargeted kinase inhibitor which potently inhibits aurora kinase A/B, JAK2/3 (IC50=1.2 nM, 1.1 nM).
Ceritinib(LDK378)
CAS 1032900-25-6
Ceritinib (LDK378) is a potent and specific ALK inhibitor with an IC50 of 0.2 nM.
N6022
CAS 1208315-24-5
N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase(GSNOR) inhibitor with IC50 of 8 nM.
Ceralasertib (AZD6738)
CAS 1352226-88-0
AZD6738 is a potent inhibitor of ATR kinase with an IC50 of 1 nM.
BGB-3111(Zanubrutinib)
CAS 1691249-45-2
Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor.
LB-100
CAS 1632032-53-1
LB-100 is a protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.
OSI-027
CAS 936890-98-1
OSI-027 is an ATP-competitive mTOR kinase activity inhibitor with an IC50 of 4 nM. OSI-027 targets both mTORC1 and mTORC2 with IC50s of 22 nM and 65 nM, respectively.
GSK-872
CAS 1346546-69-7
GSK'872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM.
CZ415
CAS 1429639-50-8
CZ415 is a potent and highly selective mTOR inhibitor with a pIC50 of 8.07. CZ415 inhibits mTORC1 and mTORC2 protein complex.
Purvalanol B(NG-95)
CAS 212844-54-7
Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.
AZD5363
CAS 1143532-39-1
Capivasertib (AZD5363) is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
TG693
CAS 885272-55-9
TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.
LDC000067
CAS 1073485-20-7
LDC000067 is a highly specific CDK9 inhibitor with an IC50 value of 44±10 nM in vitro.
AIM-100
CAS 873305-35-2
AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM.AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase [1].The Ack1 inhibitor AIM-100 not only inhibited…
Dinaciclib (SCH727965)
CAS 779353-01-4
Dinaciclib is a potent inhibitor of CDK, with IC50s of 1, 1, 3, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively.
LGX-818(Encorafenib)
CAS 1269440-17-6
Encorafenib (LGX818) is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).
BAY-293
CAS 2244904-70-7
BAY-293 is a potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction with an IC50 of 21 nM[1].
MK-3903
CAS 1219737-12-8
MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
Peficitinib（ASP015K,JNJ-54781532）
CAS 944118-01-8
Peficitinib is an oral JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
Apilimod
CAS 541550-19-0
Apilimod is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively.
GLPG-1690(Ziritaxestat)
CAS 1628260-79-6
GLPG1690 is a first-in-class autotaxin (ATX) inhibitor, with an IC50 of 131 nM and Ki of 15 nM.
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