Cancer Research
Compounds with documented oncology research applications.
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Kinases & Cell SignalingKinase inhibitors and modulators of intracellular signaling pathways.936 products →Epigenetics & Gene RegulationChromatin, transcription and epigenetic regulation.277 products →DNA Damage, Repair & Cell CycleDNA replication, repair, mitosis and cell-cycle regulation.228 products →Cell Death & AutophagyApoptosis, ferroptosis, necroptosis and autophagy research.117 products →Protein Degradation & ProteostasisPROTACs, molecular glues, ubiquitin systems, chaperones and proteostasis.173 products →Immunology & InflammationInnate and adaptive immunity, inflammatory pathways and immune signaling.297 products →NeuroscienceNeurotransmission, neural targets and neurological research.363 products →GPCRs & Receptor BiologyG-protein-coupled, nuclear and other ligand-binding receptors and their modulators.428 products →Ion Channels & TransportersIon channels, membrane transporters and pumps.196 products →Metabolism & EndocrinologyMetabolic enzymes, lipid and glucose metabolism and hormone signaling.404 products →Cardiovascular & HematologyVascular biology, coagulation, cardiac function, blood-pressure and hematology research.141 products →Anti-infectivesAntibacterial, antiviral, antifungal and antiparasitic research tools.202 products →Cancer ResearchCompounds with documented oncology research applications.530 products →ADCs & BioconjugationADC payloads, linkers, drug-linker conjugates and conjugation reagents.38 products →Probes & Assay ReagentsFluorescent and imaging probes, enzyme substrates and assay reagents.82 products →Natural ProductsNaturally occurring compounds for biological and chemical research.73 products →Cell Biology & Intracellular TransportCytoskeletal dynamics, endocytosis, vesicle trafficking, organelle function and cell differentiation.61 products →
Other Research Tools (75) · Additional reagents, building blocks and specialized research tools.
Cancer Research products
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INCB 8761
CAS 1341224-83-6
PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50 of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
5-Azacytidine
CAS 320-67-2
5-Azacytidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.
Erdafitinib
CAS 1346242-81-6
Erdafitinib (JNJ-42756493) is a potent and orally available FGFR family inhibitor; inhibits FGFR1/2/3/4 with IC50s of 1.2, 2.5, 3.0 and 5.7 nM, respectively.
Glutaminase C-IN-1
CAS 311795-38-7
Glutaminase C-IN-1 (968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts.
Dasatinib monohydrate
CAS 863127-77-9
Dasatinib monohydrate (BMS-354825 monohydrate) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Ki values of 16 pM and 30 pM for Src and Bcr-Abl, respectively[1].
BIBW2992-MA2 (Afatinib dimaleate)
CAS 850140-73-7
Afatinib dimaleate is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.
AZD-8055
CAS 1009298-09-2
AZD-8055 is a novel ATP-competitive inhibitor of mTOR kinase with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2.
ETC-159
CAS 1638250-96-0
ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
LX1606 Hippurate
CAS 1137608-69-5
Telotristat etiprate (LX1606 Hippurate) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
Crizotinib (PF-2341066)
CAS 877399-52-5
Crizotinib is a potent inhibitor of c-Met and ALK with an IC50 of 11 nM and 24 nM in cell-based assays, respectively.
Auristatin E
CAS 160800-57-7
Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.
Erlotinib hydrochloride
CAS 183319-69-9
Erlotinib hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM.
Temozolomide
CAS 85622-93-1
Temozolomide (NSC 362856; CCRG 81045) is an oral DNA alkylating agent used to treat some brain cancers.
Honokiol
CAS 35354-74-6
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt and enhances the…
Repotrectinib(TPX-005)
CAS 1802220-02-5
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
Bi 2536
CAS 755038-02-9
BI 2536 is a dual PLK1 and BRD4 inhibitor with IC50s of 0.83 and 25 nM, respectively.
Belizatinib(TSR-011)
CAS 1357920-84-3
Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.
Tariquidar (XR9576)
CAS 206873-63-4
Description of Tariquidar: Tariquidar is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of…
MC-DM1
CAS 1375089-56-7
MC-DM1 is a drug-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker MC to make antibody drug conjugate (ADC)[1].
PFK158
CAS 1462249-75-7
PFK-158 is a potent and selective inhibitor of PFKFB3 that is currently being investigated in a phase I study in patients with advanced solid malignancies.
CB1954(Tretazicar)
CAS 21919-05-1
Tretazicar (CB 1954), an antitumor prodrug, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves…
BK-1361(cyclo(RLsKDK))
CAS 1975145-82-4
BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM; displays no significant activity against ADAM 9, 10, 12, 17 , as well as MMP-2, -9, and -14 at 10 uM;…
Cyclophosphamide
CAS 50-18-0
Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
Entrectinib (RXDX-101)
CAS 1108743-60-7
Entrectinib is a potent and orally available Trk, ROS1, and ALK inhibitor; inhibits TrkA, TrkB, TrkC, ROS1 and ALK with IC50 values of 1, 3, 5, 12 and 7 nM, respectively.
SLMP53-1
CAS 1643469-17-3
A novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells; enhances p53 transcriptional activity and restores wt-like DNA binding ability to mut p53R280K; inhibits…
ML-264
CAS 1550008-55-3
ML264 is an antitumor agent that potently and selectively inhibits Krüppel-like factor five (KLF5) expression.
Doxorubicin
CAS 23214-92-8
Doxorubicin free base, also called doxorubicin, is an anthracycline antibiotic with antineoplastic activity. Approved API for cancer therapeutic use is doxorubicin HCl. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the h
Cridanimod
CAS 38609-97-1
Cridanimod is a small-molecule immunomodulator and interferon inducer[1]. Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression[2].
Fludarabine
CAS 21679-14-1
Fludarabine(NSC 118218), a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies.Fludarabine or fludarabine ph osphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers…
TAS0728
CAS 2088323-16-2
TAS0728 is a potent, selective, oral active, irreversible and covalent-binding HER2 inhibitor, binds to HER2 at C805, inhibits its kinase activity, with an IC50 of 13 nM. TAS0728 shows IC50s of 4.9, 8.5, 31, 65, 33, 25, 86 and 36 nM for BMX, HER4, BLK, EGFR,…
BAY 2416964
CAS 2242464-44-2
BAY 2416964 is a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compound and an aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. AHR antagonist 3 has anti-cancer effects[1].
Quarfloxin (CX-3543)
CAS 865311-47-3
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity.
AP24534 hydrochloride
CAS 1114544-31-8
Ponatinib, also known as AP24534 is an oral drug for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor. Some forms of CML, those that…
Masitinib
CAS 790299-79-5
Masitinib is an orally available Kit inhibitor with an IC50 of 200 nM. It also inhibits PDGFRα/β with an IC50 of 540 nM/800 nM nM.
QC-3611
CAS 1613410-75-5
QC-3611 is a selective inhibitor of JARID1A/1B, which is a target existing in various tumors (JARID1A IC50 = 13 nM ;JARID1B IC50 = 2 nM). QC-3611 is promisingly to be used as an antineoplastic drug.
INCB086550(INCB-086550)
CAS 2230911-59-6
INCB086550 is an orally available, small molecule inhibitor of PD-L1 with potential immune checkpoint inhibitory and antineoplastic activities. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and…
Miclxin
CAS 2494198-61-5
Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells
Capmatinib hydrochloride
CAS 1865733-40-9
Capmatinib, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor INC280 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting…
Elacestrant (dihydrochloride)
CAS 1349723-93-8
Elacestrant dihydrochloride (RAD1901 dihydrochloride) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively.
Niraparib tosylate hydrate
CAS 1613220-15-7
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity.
eFT508(Tomivosertib)
CAS 1849590-01-7
eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms.
6-Hydroxy-DL-DOPA
CAS 21373-30-8
6-Hydroxy-DOPA is a selective and effective allosteric inhibitor of the RAD52 ssDNA binding domain. 6-Hydroxy-DOPA can be used for the research of cancer[1].
Sotorasib racemate
CAS 2252403-56-6
Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib, a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer…
SW203668
CAS 1673556-40-5
SW203668 is a potent, tumor-specific inhibitor of stearoyl CoA desaturase (SCD) with better bioavailability than SW208108.
5-Fluorouracil
CAS 51-21-8
5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.5-Fluorouracil is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into…
Trilostane(Win 24540; Modrastane)
CAS 13647-35-3
Trilostane(Win 24540; Modrastane) is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase (3-β-HSD or delta 5-delta 4-isomerase), an essential enzyme for…
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