Ionizable Lipid Products

β-Sitosterol is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.

Stigmasterol is an orally acitve, immunomodulatory agent with anti-inflammatory and neuroprotective effect, as well as able to cross the blood-brain barrier. Stigmasterol activates AMPK, which in turn inhibits NF-κB and NLRP3 signaling pathways, reduces microglia-mediated neuroinflammation, and alleviates cognitive impairment and Alzheimer's disease. Stigmasterol regulates M1/M2 polarization of microglia through the TLR4/ NF-κB pathway, thereby reducing neuropathic pain. Stigmasterol can be used for neurodegenerative diseases, inflammatory diseases, and pain management, among others.

DC-cholesterol(3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol), a lipid, has been investigated in cancer gene therapy and vaccine delivery system.

SCS is an orally active cholesterol biosynthesis agonist that targets NPC2. It activates SREBP2 by competitively binding to NPC2, thereby promoting cholesterol synthesis (EC50 = 50 μM).

MP2 is a methylprednisolone-derived ionizable lipid studied for local colonic mRNA delivery. Its IL-35 mRNA LNP formulation was evaluated in acute and chronic colitis mouse models and ex vivo human colonic biopsies.

Lipid 03-135 is an ionizable lipid investigated for lipid nanoparticle delivery of mRNA encoding a CD19/CD3 bispecific T-cell engager developed by Abogen. In WO2024131874A1, its formulation showed the highest plotted serum antibody concentrations at 24 and 48 hours among five tested lipids after a single intravenous dose of mRNA1 in NOD/SCID mice.

Ionizable lipid used for intravenous mRNA-encoded CD19/CD3 bispecific antibody delivery and an antitumor study in a human PBMC / Nalm6 leukemia model.

Lipid 6 is a literature-reported ionizable lipid for ex vivo mRNA delivery to primary human T cells. In Gao et al. (2026), LNPs containing Lipid 6 generated MUC1-CAR T cells that were assessed against MUC1-positive cancer cell lines in vitro.

A titratable amino lipid used in nucleic-acid delivery systems and comparative LNP studies.

An early ionizable lipid used as a comparator in nucleic-acid delivery and mRNA-LNP studies.

DOTAP, also known as 1,2-Dioleoyl-3-trimethylammoniumpropane, is a cationic liposome-forming compound used for transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells. It has been used in gene delivery vectors for gene ther

NT1-O12B is a tryptamine-derived bioreducible lipidoid evaluated as a brain-delivery component. The cited study identified NT1-O12B as the strongest DiR brain-delivery member of the tested NT-lipidoid series and used it with PBA-Q76-O16B at a 3:7 weight ratio for optimized DiR and amphotericin B delivery. Results apply to these formulations and must not be extended to the NT1-O14B systems used for Tau-ASO and Cre protein delivery.

FTT5 is a lipid-like compound for efficient delivery of long mRNAs in vivo.

C24 is a novel multiprotic ionizable lipid. C24 lipid nanoparticle (LNP) has a multistage protonation behavior resulting in greater endosomal protonation and greater translation compared to the standard reference MC3 LNP. C24 LNP also lower injection site inflammation and higher stability compared to MC3 LNP.

A biodegradable ionizable lipid reference for systemic siRNA delivery and lipid-clearance research.

Lipid A9 is an ionizable cationic lipid (pKa = 6.27) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and siRNA in vivo. LNPs containing lipid A9 and encapsulating non-stimulatory siRNA increase plasma levels of chemokine (C-C motif) ligand 2 (CCL2), indicating activation of the innate immune response, and decrease body weight in mice.

A widely studied lipidoid for siRNA and mRNA delivery, including hepatic delivery comparisons.

An ionizable lipid studied for mRNA delivery to primary human T cells and ex vivo CAR-T engineering.

NT1-O14B is a tryptamine-containing cationic lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing NT1-O14B and encapsulating antisense nucleotides against tau decreases tau brain levels in mice.

DDAB is listed as a ionizable lipid for laboratory research use.