NT1-O12B
Recommended because it shares a closely related research category or delivery context. Formulation and performance are product- and study-specific.
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Ionizable lipid for LNP and nucleic-acid delivery research.
NT1-O14B is a tryptamine-containing cationic lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing NT1-O14B and encapsulating antisense nucleotides against tau decreases tau brain levels in mice.
| CAS No. | Not available |
| Chemical Name | NT1-O14B |
| Synonyms | NT1O14B, NT1 O14B |
| SMILES | O=C(OCCSSCCCCCCCCCC)CCN(CCC1=CNC2=C1C=CC=C2)CCC(OCCSSCCCCCCCCCC)=O |
| Formula | C40H68N2O4S4 |
| M.Wt | 769.230 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | 1. Ma, F., Yang, L., Sun, Z., et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Sci. Adv. 6(30), eabb4429 (2020). |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 13.0000 mL | 2.6000 mL | 1.3000 mL |
| 25 mg | 32.5000 mL | 6.5000 mL | 3.2500 mL |
| 50 mg | 65.0001 mL | 13.0000 mL | 6.5000 mL |
| 100 mg | 130.0001 mL | 26.0000 mL | 13.0000 mL |
| 250 mg | 325.0003 mL | 65.0001 mL | 32.5000 mL |
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