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CAT. NO. DC41043Featured

NT1-O12B

Research highlights

Tryptamine-derived lipidoidBioreducible disulfide tailsIntravenous brain delivery3:7 mixed-lipidoid optimum

Pack size & price

USD

Total$350

We match the best price and quality on market.

Ships from ShanghaiIce-pack transportPure lipid recommended

Product overview

Description & Application

NT1-O12B is a tryptamine-derived bioreducible lipidoid evaluated as a brain-delivery component. The cited study identified NT1-O12B as the strongest DiR brain-delivery member of the tested NT-lipidoid series and used it with PBA-Q76-O16B at a 3:7 weight ratio for optimized DiR and amphotericin B delivery. Results apply to these formulations and must not be extended to the NT1-O14B systems used for Tau-ASO and Cre protein delivery.

CAS No.	2739805-63-9
Chemical Name	NT1-O12B
Synonyms	NT1O12B，， NT1 O12B
SMILES	CCCCCCCCSSCCOC(CCN(CCC(OCCSSCCCCCCCC)=O)CCC1=CNC2=C1C=CC=C2)=O
Formula	C36H60N2O4S4
M.Wt	713.13
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Ma F, Yang L, Sun Z, et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Science Advances. 2020;6:eabb4429.

Literature-reported formulation composition

Component	Reported mass ratio (w/w)	Role
NT1-O12B	3	Ionizable lipid
PBA-Q76-O16B	7	Additional lipid components
Reported ratio sum	10	Original ratio retained

Formulation calculator unavailable. The cited 3:7 value is a weight ratio and the PBA-Q76-O16B molecular weight is not mapped, so no molar component-weight calculator is applied. Obtain and verify the complete composition and component molecular weights before planning component quantities.

N/P ratioNot reported in the cited article

Lipidoid:cargo weight ratio10:1 total lipidoid:DiR (DiR 10% w/w); the AmB loading ratio is not reported in the main text.

Buffer & pH25 mM sodium acetate, pH 5.2; ethanol removed by dialysis.

CargoDiR fluorescent dye and amphotericin B in separate experiments

Administration routeIntravenous tail-vein injection

DoseDiR-loaded LNP 1 mg/kg; amphotericin B 5 mg/kg

Animal modelMouse; strain not stated for the Fig.1-2 experiments in the main-text passages reviewed; n=4 per group for Fig.2E

Formulation processFor mixed-lipidoid formulations, NT1-O12B and PBA-Q76-O16B were dissolved together in ethanol at the reported weight ratio, added dropwise to sodium acetate buffer and dialyzed to remove ethanol. The main text identifies 3:7 w/w as the best mixed ratio for DiR and AmB brain delivery.

Literature-reported performance for the cited formulation

Literature-reportedBrain DiR fluorescence4.5-fold higher than pure NT1-O12B formulationNT1-O12B/PBA-Q76-O16B = 3:7 w/w; DiR at 10% w/w; LNP dose 1 mg/kg IV · 1 h · Pure NT1-O12B/DiR formulationPMC full text Results; Fig.2D and cited Fig.S8

Literature-reportedAmphotericin B concentration in brainAround 300 ng/g tissueNT1-O12B/PBA-Q76-O16B = 3:7 w/w; amphotericin B 5 mg/kg IV · 24 h · About twofold higher than pure NT1-O12B; pure PBA-Q76-O16B was nearly undetectable in brainPMC full text Results and Fig.2E; n=4 per group

Literature-reportedPure NT1-O12B amphotericin B brain concentrationAround 150 ng/g tissuePure NT1-O12B formulation; amphotericin B 5 mg/kg IV · 24 hPMC full text Results; cited Fig.S6

Literature Data DisclaimerAll formulation parameters and performance values shown in this section are derived from the cited publication and are provided for reference only. These results were obtained using the specific materials, formulation process, cargo, dose, analytical method, model and administration route described in that study. Unless otherwise stated, the data were not generated or independently verified by DC Chemicals. DC Chemicals supplies the lipid compound only and does not guarantee that customers will reproduce the reported LNP properties or biological performance.

The administration route shown above was used in the cited study and is not a clinical-use instruction or recommendation by DC Chemicals.

Cited literature for this formulation and performance datasetMa F, Yang L, Sun Z, et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Science Advances. 2020;6:eabb4429. DOI: 10.1126/sciadv.abb4429
NT1-O12B-specific claims are restricted to the DiR and amphotericin B experiments in Figs.1-2. NT1-O14B biomacromolecule-delivery results are excluded.

Primary article

Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Do not normalize 3:7 w/w as mol%. Do not infer N/P.

Mass = concentration × volume × molecular weight

MassConcentrationVolumeMolecular weightg/mol

Enter any three values to calculate the fourth.

C₁V₁ = C₂V₂

C₁mMV₁mLC₂mMV₂mL

Enter any three values to calculate the fourth.

Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass	1 mM	5 mM	10 mM
10 mg	14.0227 mL	2.8045 mL	1.4023 mL
25 mg	35.0567 mL	7.0113 mL	3.5057 mL
50 mg	70.1134 mL	14.0227 mL	7.0113 mL
100 mg	140.2269 mL	28.0454 mL	14.0227 mL
250 mg	350.5672 mL	70.1134 mL	35.0567 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?

We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.

Pure lipid or solution — which should I choose?

Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.

How should I measure a small amount of oily or viscous lipid?

Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.

Can you support formulation optimization and scale-up?

Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.

NT1-O12B

Pack size & price

Description & Application

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