Literature-reported formulation composition
Component: NT1-O12B | Reported mass ratio (w/w): 3 | Role: Ionizable lipid
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NT1-O12B
Literature records
Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.
Literature-reported formulation composition
Component: PBA-Q76-O16B | Reported mass ratio (w/w): 7 | Role: Additional lipid components
Literature-reported formulation composition
Component: Reported ratio sum | Reported mass ratio (w/w): 10 | Role: Original ratio retained
Reported observation
Literature-reported Brain DiR fluorescence 4.5-fold higher than pure NT1-O12B formulation NT1-O12B/PBA-Q76-O16B = 3:7 w/w; DiR at 10% w/w; LNP dose 1 mg/kg IV · 1 h · Pure NT1-O12B/DiR formulation PMC full text Results; Fig.2D and cited Fig.S8
Reported observation
Literature-reported Amphotericin B concentration in brain Around 300 ng/g tissue NT1-O12B/PBA-Q76-O16B = 3:7 w/w; amphotericin B 5 mg/kg IV · 24 h · About twofold higher than pure NT1-O12B; pure PBA-Q76-O16B was nearly undetectable in brain PMC full text Results and Fig.2E; n=4 per group
Reported observation
Literature-reported Pure NT1-O12B amphotericin B brain concentration Around 150 ng/g tissue Pure NT1-O12B formulation; amphotericin B 5 mg/kg IV · 24 h PMC full text Results; cited Fig.S6