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DC41043 · Updated 24 October 2026

NT1-O12B
Formulation & Performance

This edition organizes the previously reviewed, source-linked product record. It is not a new independent review of every paper or supporting file. Reported and calculated values retain their original labels.

Literature-reported formulation composition

ComponentReported mass ratio (w/w)Role
NT1-O12B3Ionizable lipid
PBA-Q76-O16B7Additional lipid components
Reported ratio sum10Original ratio retained
Formulation calculator unavailable. The cited 3:7 value is a weight ratio and the PBA-Q76-O16B molecular weight is not mapped, so no molar component-weight calculator is applied. Obtain and verify the complete composition and component molecular weights before planning component quantities.
Not reported in the cited article
10:1 total lipidoid:DiR (DiR 10% w/w); the AmB loading ratio is not reported in the main text.
25 mM sodium acetate, pH 5.2; ethanol removed by dialysis.
DiR fluorescent dye and amphotericin B in separate experiments
Intravenous tail-vein injection
DiR-loaded LNP 1 mg/kg; amphotericin B 5 mg/kg
Mouse; strain not stated for the Fig.1-2 experiments in the main-text passages reviewed; n=4 per group for Fig.2E
For mixed-lipidoid formulations, NT1-O12B and PBA-Q76-O16B were dissolved together in ethanol at the reported weight ratio, added dropwise to sodium acetate buffer and dialyzed to remove ethanol. The main text identifies 3:7 w/w as the best mixed ratio for DiR and AmB brain delivery.

Literature-reported performance for the cited formulation

Literature-reported4.5-fold higher than pure NT1-O12B formulationNT1-O12B/PBA-Q76-O16B = 3:7 w/w; DiR at 10% w/w; LNP dose 1 mg/kg IV · 1 h · Pure NT1-O12B/DiR formulationPMC full text Results; Fig.2D and cited Fig.S8
Literature-reportedAround 300 ng/g tissueNT1-O12B/PBA-Q76-O16B = 3:7 w/w; amphotericin B 5 mg/kg IV · 24 h · About twofold higher than pure NT1-O12B; pure PBA-Q76-O16B was nearly undetectable in brainPMC full text Results and Fig.2E; n=4 per group
Literature-reportedAround 150 ng/g tissuePure NT1-O12B formulation; amphotericin B 5 mg/kg IV · 24 hPMC full text Results; cited Fig.S6
Literature Data DisclaimerAll formulation parameters and performance values shown in this section are derived from the cited publication and are provided for reference only. These results were obtained using the specific materials, formulation process, cargo, dose, analytical method, model and administration route described in that study. Unless otherwise stated, the data were not generated or independently verified by DC Chemicals. DC Chemicals supplies the lipid compound only and does not guarantee that customers will reproduce the reported LNP properties or biological performance.

The administration route shown above was used in the cited study and is not a clinical-use instruction or recommendation by DC Chemicals.
Cited literature for this formulation and performance datasetMa F, Yang L, Sun Z, et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Science Advances. 2020;6:eabb4429. DOI: 10.1126/sciadv.abb4429
NT1-O12B-specific claims are restricted to the DiR and amphotericin B experiments in Figs.1-2. NT1-O14B biomacromolecule-delivery results are excluded.

Primary article