Literature-reported formulation composition
Component: NT1-O14B | Reported mass ratio (w/w): 3 | Role: Ionizable lipid
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NT1-O14B
Literature records
Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.
Literature-reported formulation composition
Component: 306-O12B-3 | Reported mass ratio (w/w): 7 | Role: Additional lipid components
Literature-reported formulation composition
Component: DSPE-PEG2000 (1 part per 24 parts mixed synthetic lipids) | Reported mass ratio (w/w): 1:24 | Role: PEG lipid
Literature-reported formulation composition
Component: Reported ratio sum | Reported mass ratio (w/w): Not reported | Role: Original ratio retained
Reported observation
Literature-reported Brain tau mRNA reduction Approximately 50% NT1-O14B/306-O12B-3 = 3:7 w/w; Tau-ASO:total lipids = 1:15 w/w; 1 mg/kg IV ×5 · Brain collected on day 20 · Pure NT1-O14B, pure 306-O12B-3, saline and scrambled ASO controls did not show the same reduction Main Results and Fig.3C
Reported observation
Literature-reported Brain total tau protein reduction Approximately 30% NT1-O14B/306-O12B-3 = 3:7 w/w; same Tau-ASO regimen · Day 20 · Saline and scrambled Tau-ASO Main Discussion and Fig.3D
Reported observation
Estimated from figure ASO-loaded particle characterization About 175 nm, PDI about 0.18 and zeta potential about -16 mV NT1-O14B/306-O12B-3 = 3:7 w/w with ASO Approximate readings from plotted bars; the supplement does not print a numeric table. Supplementary Fig.S10A-B, pp.14-15
Reported observation
Cre-protein formulation NT1-O14B/PBA-Q76-O16B = 3:7 w/w was mixed with (-27)GFP-Cre at protein:lipids = 1:4 w/w for 15 min. Four 50-microgram IV injections on days 0, 5, 10 and 15 produced tdTomato-positive cells in cerebral cortex, hippocampus and cerebellum; pure-lipid controls did not. Ai14 mice, n=3 per group; brain collected day 20 · Main Fig.4 and Methods: In vivo delivery of GFP-Cre protein
Reported observation
Cre-loaded particle characterization Supplementary Fig.S10 shows approximately 142 nm diameter, PDI approximately 0.24 and zeta potential approximately +15 mV for the loaded 3:7 NT1-O14B/PBA-Q76-O16B formulation. Approximate values read from plotted bars; not a numeric table · Supplementary Fig.S10A-B, pp.14-15