C12-200
Recommended because it shares a closely related research category or delivery context. Formulation and performance are product- and study-specific.
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Ionizable lipid for LNP and nucleic-acid delivery research.
Lipid A9 is an ionizable cationic lipid (pKa = 6.27) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and siRNA in vivo. LNPs containing lipid A9 and encapsulating non-stimulatory siRNA increase plasma levels of chemokine (C-C motif) ligand 2 (CCL2), indicating activation of the innate immune response, and decrease body weight in mice.
| CAS No. | Not available |
| Chemical Name | Acuitas A9 |
| Synonyms | Lipid A9,Acuitas A9 |
| SMILES | CCCCCCCCC(=O)N(CCCN(C)C)C(CCCCCCCCC(=O)OCC(CCCC)CCCCCC)CCCCCCCCC(=O)OCC(CCCC)CCCCCC |
| Formula | C57H112N2O5 |
| M.Wt | 905.51 |
| Purity | >95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | 1. Buschmann, M.D., Carrasco, M.J., Alishetty, S., et al. Nanomaterial delivery systems for mRNA vaccines. Vaccines (Basel) 9(1), 65 (2021). 2. Holland, R., Lam, K., Jeng, S., et al. Silicon ether ionizable lipids enable potent mRNA lipid nanoparticles with rapid tissue clearance. ACS Nano 18(15), 10374-10387 (2024). |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 11.0435 mL | 2.2087 mL | 1.1044 mL |
| 25 mg | 27.6088 mL | 5.5218 mL | 2.7609 mL |
| 50 mg | 55.2175 mL | 11.0435 mL | 5.5218 mL |
| 100 mg | 110.4350 mL | 22.0870 mL | 11.0435 mL |
| 250 mg | 276.0875 mL | 55.2175 mL | 27.6088 mL |
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