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Ionizable lipids / ATX-126(ATX-0126, lipid 10p)
ATX-126(ATX-0126, lipid 10p) chemical structure
Product imageResearch use only
CAT. NO. DC57046Featured

ATX-126(ATX-0126, lipid 10p)

Pack size & price

USD
TotalUS$350
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

ATX-126 is a thiocarbamate-containing ionizable lipid investigated in siRNA nanoparticles and identified as an LNP component in the PMDA assessment of Kostaive.

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Literature evidence · DC57046

Formulation & Performance

The published lipid 10p study provides a defined siRNA screening composition and mouse Factor VII silencing data. Separate regulatory studies describe tissue persistence after intramuscular administration; these results belong to different formulations and routes.

ATX-126 is identified by chemical name in the PMDA report and matches lipid 10p in Rajappan et al. The mouse siRNA screen and the regulatory vaccine studies are presented as separate evidence records.

Formulation components and molecular-weight conversion

ComponentDC Chemicals productMolecular weightMolar ratioMass at 1 µmol total lipid (mg)
ATX-126DC57046755.23580.438033
DSPCDC57005790.1570.055311
CholesterolDCD-041386.6533.50.129528
DMG-PEG2000DC4016925071.50.037605

Rajappan 2020 siRNA formulation: 58:7:33.5:1.5 mol%; total lipid:RNA approximately 30:1 by mass. The 30:1 ratio is not N/P. DMG-PEG2000 MW 2507 follows the catalog calculation convention. This is not asserted to be the Kostaive manufacturing composition.

Component mass calculator

Prefilled proportions follow the source specified above. Molecular weights and ratios are editable. Results are calculated, not measured study data. No N/P or RNA dose is inferred.

ComponentMWMolar ratioMass (mg)Mass %
ATX-126——
DSPC——
Cholesterol——
DMG-PEG2000——

Formulation and particle evidence

ParameterReported findingSource
Apparent pKa6.38 in the formulated-lipid studyRajappan 2020, Table 8
siRNA encapsulationThe study reports >90% across its tested lipid formulationsExperimental Section: siRNA Formulation into Lipid Nanoparticles
Regulatory LNP componentsATX-126, DSPC, cholesterol, PEG2000-DMG; ratio not assigned herePMDA PDF p9, section 2.2.1

Mouse biological results

StudyFindingInterpretation
FVII siRNA, female BALB/c mice, intravenous, 48-hour endpoint99% FVII knockdown at 0.03 mg/kg siRNALipid 10p, Tables 7–8; target-specific knockdown, not general mRNA efficacy
Mouse plasma stability100% lipid remaining at 2 hoursTable 8; does not support a rapid-clearance claim
Short mouse tolerability studyNo abnormal observations reported at 3 mg/kg siRNANontargeting-siRNA LNP assessment with 72-hour observation; not chronic or human safety

Regulatory biodistribution context

ContextFindingBoundary
ARCT-021 repeated intramuscular rabbit studyATX-126 remained detectable in liver, spleen, muscle and ovary on Day 57; no histopathological findings of toxicological significance were reported in these tissuesPMDA PDF pp16–17, section 4.2.2; not the intravenous siRNA formulation
ATX-126 metabolism assessmentSlow turnover and prolonged tissue persistence are describedPMDA PDF pp17–19; ester groups alone do not establish rapid elimination

References and source locations

  1. Rajappan K, et al. Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA. J Med Chem 63 (2020), 12992–13012.
  2. PMDA. Kostaive Intramuscular Injection review report. Sections 2.2.1, 4.2.2 and 4.3.
CAS No.2230647-37-5
Chemical NameATX-126(ATX-0126, lipid 10p)
SynonymsATX126， ATX 126,ATX 0126, ATX0126,ATX100,ATX-100, ATX 100
SMILESCCCCCCCC(CCCCCCC)OC(=O)CCCN(CCCC(=O)OC(CCCCCCC)CCCCCCC)C(=O)SCCCN(C)C
FormulaC44H86N2O5S
M.Wt755.23
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
Publication
  1. Rajappan K, et al. Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA. J Med Chem 63 (2020), 12992–13012.
  2. PMDA. Kostaive Intramuscular Injection review report. Sections 2.2.1, 4.2.2 and 4.3.
F&PFormulation & PerformanceComposition, study results and referencesRead online →
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg13.2410 mL2.6482 mL1.3241 mL
25 mg33.1025 mL6.6205 mL3.3102 mL
50 mg66.2050 mL13.2410 mL6.6205 mL
100 mg132.4100 mL26.4820 mL13.2410 mL
250 mg331.0250 mL66.2050 mL33.1025 mL

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.