DLin-MC3-DMA
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Ionizable lipid for LNP and nucleic-acid delivery research.
ATX-126(ATX-0126, 10p) is an ionizable cationic lipid (pKa = 6.38).It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA. Intravenous administration of LNPs containing ATX-126(ATX-0126, 10p) and encapsulating Factor VII siRNA decrease Factor VII blood levels in mice.
| CAS No. | Not available |
| Chemical Name | ATX-126(ATX-0126, lipid 10p) |
| Synonyms | ATX126, ATX 126,ATX 0126, ATX0126,ATX100,ATX-100, ATX 100 |
| SMILES | CCCCCCCC(CCCCCCC)OC(=O)CCCN(CCCC(=O)OC(CCCCCCC)CCCCCCC)C(=O)SCCCN(C)C |
| Formula | C44H86N2O5S |
| M.Wt | 755.23 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | 1. Rajappan, K., Tanis, S.P., Roberts, S., et al. Development of a safe and scalable process for the production of a high-purity thiocarbamate-based ionizable lipid as an excipient in mRNA-encapsulating lipid nanoparticles. Org. Process Res. Dev. 25(6), 1383-1390 (2021). 2. Rajappan, K., Tanis, S.P., Mukthavaram, R., et al. Property-driven design and development of lipids for efficient delivery of siRNA. J. Med. Chem. 63(21), 12992-13012 (2020). |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 13.2410 mL | 2.6482 mL | 1.3241 mL |
| 25 mg | 33.1025 mL | 6.6205 mL | 3.3102 mL |
| 50 mg | 66.2050 mL | 13.2410 mL | 6.6205 mL |
| 100 mg | 132.4100 mL | 26.4820 mL | 13.2410 mL |
| 250 mg | 331.0250 mL | 66.2050 mL | 33.1025 mL |
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