PRODUCT DATASHEET · DC57046
ATX-126(ATX-0126, lipid 10p)
Version 1.be714bb4 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | ATX-126(ATX-0126, lipid 10p) |
| Synonyms | ATX126， ATX 126,ATX 0126, ATX0126,ATX100,ATX-100, ATX 100 |
| SMILES | CCCCCCCC(CCCCCCC)OC(=O)CCCN(CCCC(=O)OC(CCCCCCC)CCCCCCC)C(=O)SCCCN(C)C |
| Formula | C44H86N2O5S |
| M.Wt | 755.23 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | 1. Rajappan, K., Tanis, S.P., Roberts, S., et al. Development of a safe and scalable process for the production of a high-purity thiocarbamate-based ionizable lipid as an excipient in mRNA-encapsulating lipid nanoparticles. Org. Process Res. Dev. 25(6), 1383-1390 (2021). 2. Rajappan, K., Tanis, S.P., Mukthavaram, R., et al. Property-driven design and development of lipids for efficient delivery of siRNA. J. Med. Chem. 63(21), 12992-13012 (2020). |
ATX-126(ATX-0126, 10p) is an ionizable cationic lipid (pKa = 6.38).It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA. Intravenous administration of LNPs containing ATX-126(ATX-0126, 10p) and encapsulating Factor VII siRNA decrease Factor VII blood levels in mice.
Specifications shown are product-page values, not batch test results.
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