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Ionizable lipids / Arcturus lipid 2(ATX-0114)
Arcturus lipid 2(ATX-0114) chemical structure
Product imageResearch use only
CAT. NO. DC59217Featured

Arcturus lipid 2(ATX-0114)

Pack size & price

USD
Total$600
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

ATX-0114, also listed as Arcturus lipid 2, is an ionizable lipid reported in patent US20180170866A1. The patent screening table associates compound 0114 with 90% in vivo factor VII knockdown at 0.03 mg/kg and a measured formulation pKa of 6.69. The row does not disclose a complete product-specific formulation.

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Literature evidence · DC59217

Formulation & Performance

The patent supports a specific screening result. Exact component ratios, particle attributes and experimental context are not substituted from the broader patent platform.

The results below describe the cited research formulations. Product specifications and commercial pack options are shown in the Specifications and ordering sections.

Formulation components and molecular-weight conversion

Complete component identities and quantitative proportions were not established in the available source. No surrogate four-component formulation is assigned.

The available ATX-0114 row does not establish a complete formulation. Helper-lipid identities and ratios, PEG-lipid identity, N/P and RNA loading ratio are left unassigned. Generic ranges elsewhere in the patent are not an ATX-0114 recipe.

Patent screening result

ParameterCompound 0114 entryEvidence location
In vivo bioactivity90% factor VII knockdownExample 1, paragraph [0188], Table 1; printed p. 25 (PDF p. 45).
RNA dose for the table endpoint0.03 mg/kgTable 1 endpoint heading, unless otherwise indicated.
Measured pKa6.69Reported formulation pKa. The patent describes measurements on LNP or micelle formulations.

Computed versus measured properties

PropertyReported valueInterpretation
cLogD11.06Computed descriptor; not a measured distribution or pharmacokinetic result.
cpKa9.59Computed value; not interchangeable with measured formulation pKa.
Formulation pKa6.69Measured screening property; the full associated composition is not specified in the row.

Experimental context not established for the row

FieldStatusConsequence
Species, route, sampling time and replicate countNot specified in the compound 0114 rowNot inferred from unrelated examples.
Exact component identities / molar ratiosNot established for this rowNo filled four-component recipe or mass-fraction calculator is presented.
Size, PDI, encapsulation and N/PNo compound-specific values establishedPlatform-wide ranges are not assigned to ATX-0114.
mRNA expression or vaccine efficacyNot the endpoint in Table 1The factor VII result is a knockdown endpoint.

Tolerability and evidence scope

QuestionAvailable evidenceInterpretation
Product-specific toxicityNo matched toxicity dataset established for the Table 1 rowNo safe dose or superiority claim is assigned.
Evidence typePatent screening entryUseful as research provenance; not a clinical performance claim or an independently replicated efficacy result.

Original study figures

Original patent, Example 1 and Table 1 — Original source figures.

References and source locations

  1. Payne JE, Chivukula P, et al. Ionizable Cationic Lipid for RNA Delivery. US20180170866A1, published 21 June 2018. Example 1, Table 1.
CAS No.2230647-30-8
Chemical NameArcturus lipid 2(ATX-0114)
SynonymsATX0114， ATX 0114
SMILESCN(C)CCCCSC(=O)N(CC(=O)OC/C=C\CCCCCC)CC(=O)OC(CCCCCCCC)CCCCCCCC
FormulaC37H70N2O5S
M.Wt654.50
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
Publication
  1. Payne JE, Chivukula P, et al. Ionizable Cationic Lipid for RNA Delivery. US20180170866A1, published 21 June 2018. Example 1, Table 1.
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Measured formulation pKa 6.69 is shown as a patent-reported LNP value; no N/P is inferred.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg15.2788 mL3.0558 mL1.5279 mL
25 mg38.1971 mL7.6394 mL3.8197 mL
50 mg76.3942 mL15.2788 mL7.6394 mL
100 mg152.7884 mL30.5577 mL15.2788 mL
250 mg381.9710 mL76.3942 mL38.1971 mL

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.