DLin-MC3-DMA
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Ionizable lipid for LNP and nucleic-acid delivery research.
Lipid 2,2(8,8) 4C CH3 is an ionizable cationic lipid (pKa = 6.69).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vivo. LNPs containing lipid 2,2(8,8) 4C CH3 and encapsulating siRNA targeting Factor VII decrease plasma Factor VII protein levels by 90% in mice.
| CAS No. | Not available |
| Chemical Name | Arcturus lipid 2(ATX-0114) |
| Synonyms | ATX0114, ATX 0114 |
| SMILES | CN(C)CCCCSC(=O)N(CC(=O)OC/C=C\CCCCCC)CC(=O)OC(CCCCCCCC)CCCCCCCC |
| Formula | C37H70N2O5S |
| M.Wt | 654.50 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Payne, J. E. & Chivukula P. Ionizable Cationic Lipid for RNA Delivery. https://patents.google.com/patent/US9670152B2/en. |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 15.2788 mL | 3.0558 mL | 1.5279 mL |
| 25 mg | 38.1971 mL | 7.6394 mL | 3.8197 mL |
| 50 mg | 76.3942 mL | 15.2788 mL | 7.6394 mL |
| 100 mg | 152.7884 mL | 30.5577 mL | 15.2788 mL |
| 250 mg | 381.9710 mL | 76.3942 mL | 38.1971 mL |
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