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Arcturus lipid 2(ATX-0114)

Version 1.b0c402fe · 2026-09-13

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CAS No.Not available
Chemical NameArcturus lipid 2(ATX-0114)
SynonymsATX0114, ATX 0114
SMILESCN(C)CCCCSC(=O)N(CC(=O)OC/C=C\CCCCCC)CC(=O)OC(CCCCCCCC)CCCCCCCC
FormulaC37H70N2O5S
M.Wt654.50
PurityELSD-HPLC>95%
StorageOriginal product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationPayne, J. E. & Chivukula P. Ionizable Cationic Lipid for RNA Delivery. https://patents.google.com/patent/US9670152B2/en.

Lipid 2,2(8,8) 4C CH3 is an ionizable cationic lipid (pKa = 6.69).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vivo. LNPs containing lipid 2,2(8,8) 4C CH3 and encapsulating siRNA targeting Factor VII decrease plasma Factor VII protein levels by 90% in mice.

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