DC57046 · Updated 27 October 2026
ATX-126 (ATX-0126, lipid 10p)
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 1.3241 mL | 0.6620 mL |
| 25 mg | 3.3102 mL | 1.6551 mL |
| 50 mg | 6.6205 mL | 3.3102 mL |
| 100 mg | 13.2410 mL | 6.6205 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Molar ratio | Mass at 1 µmol total lipid (mg) |
|---|---|---|---|---|
| ATX-126 | DC57046 | 755.23 | 58 | 0.438033 |
| DSPC | DC57005 | 790.15 | 7 | 0.055311 |
| Cholesterol | DCD-041 | 386.65 | 33.5 | 0.129528 |
| DMG-PEG2000 | DC40169 | 2507 | 1.5 | 0.037605 |
Rajappan 2020 siRNA formulation: 58:7:33.5:1.5 mol%; total lipid:RNA approximately 30:1 by mass. The 30:1 ratio is not N/P. DMG-PEG2000 MW 2507 follows the catalog calculation convention. This is not asserted to be the Kostaive manufacturing composition.
Read the complete study conditions, biological results, tolerability and figures →