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Acuitas A9

Version 1.707d62ff · 2026-09-13

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CAS No.Not available
Chemical NameAcuitas A9
SynonymsLipid A9,Acuitas A9
SMILESCCCCCCCCC(=O)N(CCCN(C)C)C(CCCCCCCCC(=O)OCC(CCCC)CCCCCC)CCCCCCCCC(=O)OCC(CCCC)CCCCCC
FormulaC57H112N2O5
M.Wt905.51
Purity>95%
StorageOriginal product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
Publication1. Buschmann, M.D., Carrasco, M.J., Alishetty, S., et al. Nanomaterial delivery systems for mRNA vaccines. Vaccines (Basel) 9(1), 65 (2021). 2. Holland, R., Lam, K., Jeng, S., et al. Silicon ether ionizable lipids enable potent mRNA lipid nanoparticles with rapid tissue clearance. ACS Nano 18(15), 10374-10387 (2024).

Lipid A9 is an ionizable cationic lipid (pKa = 6.27) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and siRNA in vivo. LNPs containing lipid A9 and encapsulating non-stimulatory siRNA increase plasma levels of chemokine (C-C motif) ligand 2 (CCL2), indicating activation of the innate immune response, and decrease body weight in mice.

Specifications shown are product-page values, not batch test results.

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