Ionizable Lipid Products

Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension.

HG106 is a potent SLC7A11 inhibitor and enhances ROS generation, ER stress, and ultimately growth arrest specifically in KRAS-mutant lung adenocarcinoma (LUAD).

GRK6 inhibitor 18 is a potent, and selective GRK6 inhibitor with IC50 of 8 nM. GRK6 inhibitor 18 displays >1,000-fold selectivity over Aurora A, as well as high selectivity against a panel of 85 kinases. GRK6 inhibitor 18 has potent cellular target engagement and antiproliferative activity against MM cells (IC50=0.4-0.46 uM) and is synergistic with bortezomib.

Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator.

For the detailed information of Rifabutin (Mycobutin), the solubility of Rifabutin (Mycobutin) in water, the solubility of Rifabutin (Mycobutin) in DMSO, the solubility of Rifabutin (Mycobutin) in PBS buffer, the animal experiment（test） (test) of Rifabutin (Mycobutin), the cell expriment (test) of Rifabutin (Mycobutin), the in vivo, in vitro and clinical trial test of Rifabutin (Mycobutin), the EC50, IC50,and Affinity of Rifabutin (Mycobutin),, please contact DC Chemicals.

S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.

For the detailed information of Vitamin A, the solubility of Vitamin A in water, the solubility of Vitamin A in DMSO, the solubility of Vitamin A in PBS buffer, the animal experiment（test） (test) of Vitamin A, the cell expriment (test) of Vitamin A, the in vivo, in vitro and clinical trial test of Vitamin A, the EC50, IC50,and Affinity of Vitamin A,, please contact DC Chemicals.

N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.

QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC).QC-01–175 effected clearance of tau in frontotemporal dementia (FTD) patient-derived neuronal cell models, with minimal effect on tau from neurons of healthy controls.QC-01–175 also rescued stress vulnerability in FTD neurons, phenocopying CRISPR-mediated MAPT-knockout.

Zinc Pyrithione is a dimer of two pyrithione molecules bound by zinc. It is commonly found as an ingredient of commercial anti-dandruff shampoos. This products acts as an antifungal and antibacterial.

For the detailed information of Ozagrel HCl, the solubility of Ozagrel HCl in water, the solubility of Ozagrel HCl in DMSO, the solubility of Ozagrel HCl in PBS buffer, the animal experiment（test） (test) of Ozagrel HCl, the cell expriment (test) of Ozagrel HCl, the in vivo, in vitro and clinical trial test of Ozagrel HCl, the EC50, IC50,and Affinity of Ozagrel HCl,, please contact DC Chemicals.

Methotrexate(WR19039; CL14377) can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.in vitro: In normal T cells, Methotrexate (MTX) produced a dose-dependent reduction in de novo adenosine and guanosine pools with maximal effects (>50%) at 1 microM MTX. In CEM cells, de novo purine synthesis was almost completely blocked by 1 microM MTX. Total purine pools were also reduced in both cell types after MTX treatment. JAR cells underwent apoptosis after exposure to 0.1-2.5 microg/ml MTX for 48 h. Decreased mitochondrial membrane potential was observed both by fluorescence microscopy and FCM. The activation of caspase-9 was increased 4.35+/-0.76-fold in MTX-incubated JAR, while there was no obvious change in the activation of caspase-8. in vivo: Three, four and five weeks after consecutive administration of MTX (3 mg/kg/day), hydroxyproline content in the lung tissues increased significantly to about 2 times higher that of the control level. MTX was administered intraperitoneally (ip) at the doses of 5, 10, 20 and 40 mg/kg to mice (20-25 g) weekly once (wk) for 5 and 10 weeks. The animals were sacrificed 1 week after receiving the last treatment of MTX. The germ cell toxicity was evaluated using testes weight (wt), sperm count, sperm head morphology, sperm comet assay, histology, TUNEL and halo assay in testis. MTX treatment significantly reduced the sperm count and increased the occurrence of sperm head abnormalities in a dose dependent manner.

Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. Dienogest is an orally active synthetic progesterone (or progestin). It is available for use as an oral contraceptive in combination with ethinylestradiol. It has antiandrogenic activity and as a result can improve androgenic symptoms. It is a non-ethinylated progestin which is structurally related to testosterone. Complete sperm suppression was observed in rats sacrificed either 60 or 90 days after dienogest (DNG)+ testosterone undecanoate (TU) administration, for two injections at 45-day interval. The neutral α-glucosidase activity in these treated rats remained in the normal range. Germ cell loss due to apoptosis was frequently observed both after 60 or 90 days of combination treatment. Significant decline in serum gonadotropin and testosterone, both serum and intratesticular levels, were observed in the treated rats. Following stoppage of treatment (given at 45-day interval) after two (0 and 45 days) or three injections (0, 45 and 90 days), complete restoration of spermatogenesis was observed by 120 and 165 days, respectively.

For the detailed information about the solubility of Rhoifolin in water, the solubility of Rhoifolin in DMSO, the solubility of Rhoifolin in PBS buffer, the animal experiment（test） of Rhoifolin,the in vivo,in vitro and clinical trial test of Rhoifolin,the cell experiment（test） of Rhoifolin,the IC50, EC50 and Affinity of Rhoifolin, please contact DC Chemicals.

Luteolin is a falconoid compound, which exhibits anticancer properties.IC50 value:Target: A natural for anticancer.

GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively.

ICCB-19 inhibits RIPK1-dependent apoptosis (RDA) with IC50 of 2.01 μM.

Ezetimibe (SCH 58235) is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor.

LGD-3303 is a selective androgen receptor modulator (SARM).

CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM.