N-Desmethyl Pimavanserin chemical structure
Chemical structureResearch use only
CAT. NO. DC28845Featured

N-Desmethyl Pimavanserin

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Product overview

Description & Application

N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.

ParameterValue
Chemical NameN-Desmethyl Pimavanserin
CAS No.639863-77-7
SynonymsCXL6LOR95E;N-Desmethyl-pimavanserin;n-(4-fluorobenzyl)-n-(piperidin-4-yl)-n'-(4-isobutyloxybenzyl)carbamide;Urea, N-((4-fluorophenyl)methyl)-N'-((4-(2-methylpropoxy)phenyl)methyl)-N-4-piperidinyl-;Unii-cxl6lor95E;AC-279;N-Desmethyl Pimavanserin
FormulaC24H32FN3O2
M.Wt413.528189659119
SMILESFC1C=CC(=CC=1)CN(C(NCC1C=CC(=CC=1)OCC(C)C)=O)C1CCNCC1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.

In Vitro

The mean plasma half-lives for Pimavanserin and its metabolite N-Desmethyl Pimavanserin (AC-279) are 57 hours and 200 hours, respectively.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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